三思而后行：液体活检在儿童高级别胶质瘤中的前景
Measure Twice: Promise of Liquid Biopsy in Pediatric High-Grade Gliomas.
作者信息
Dietz Matthew S, Beach Catherine Z, Barajas Ramon, Parappilly Michael S, Sengupta Sidharth K, Baird Lissa C, Ciporen Jeremy N, Han Seunggu J, Loret de Mola Rebecca, Cho Yoon Jae, Nazemi Kellie J, McClelland Shearwood, Wong Melissa H, Jaboin Jerry J
机构信息
Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.
Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon.
出版信息
Adv Radiat Oncol. 2020 Jan 28;5(2):152-162. doi: 10.1016/j.adro.2019.12.008. eCollection 2020 Mar-Apr.
PURPOSE
To review and critique the current state of liquid biopsy in pHGG.
MATERIALS AND METHODS
Published literature was reviewed for articles related to liquid biopsy in pediatric glioma and adult glioma with a focus on high-grade gliomas.
RESULTS
This review discusses the current state of liquid biomarkers of pHGG and their potential applications for liquid biopsy development.
CONCLUSIONS
While nascent, the progress toward identifying circulating analytes of pHGG primes the field of neuro-oncoogy for liquid biopsy development.
目的
回顾和评价pHGG中液体活检的当前状况。
材料与方法
检索已发表的文献，查找与小儿胶质瘤和成人胶质瘤中液体活检相关的文章，重点关注高级别胶质瘤。
结果
本综述讨论了pHGG液体生物标志物的当前状况及其在液体活检发展中的潜在应用。
结论
虽然尚处于初期阶段，但在识别pHGG循环分析物方面取得的进展为神经肿瘤学领域开展液体活检奠定了基础。
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