Jenkins Ian D, Krenske Elizabeth H
Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
ACS Omega. 2020 Mar 23;5(13):7053-7058. doi: 10.1021/acsomega.0c00366. eCollection 2020 Apr 7.
The hydrosilane/potassium -butoxide reagent system has attracted significant attention over the last 5 years since the discovery of its ability to silylate heteroarene C-H bonds. Numerous useful HSiR/KO Bu-mediated transformations are now known, including silylation of sp, sp, and sp C-H bonds, reductive cleavage of C-O, C-S, and C-N bonds, reduction of polycyclic arenes, and hydrosilylation and polymerization of styrenes. This mini-review surveys the rich diversity of reaction mechanisms, both ionic and free radical and including hydride transfer, H atom transfer, and electron transfer, that have been uncovered during recent studies on the HSiR/KO Bu reagent system. Several mechanistic phenomena that remain to be explained are also highlighted.
自发现氢硅烷/丁醇钾试剂体系能够硅烷化杂芳烃C-H键以来，在过去5年中该体系已引起了广泛关注。目前已知许多有用的HSiR/KO Bu介导的转化反应，包括 sp、sp 和 sp C-H 键的硅烷化、C-O、C-S 和 C-N 键的还原裂解、多环芳烃的还原以及苯乙烯的硅氢化和聚合反应。本综述概述了近期关于HSiR/KO Bu试剂体系的研究中所揭示的丰富多样的反应机理，包括离子型和自由基型，以及氢化物转移、H原子转移和电子转移等。同时也强调了一些有待解释的机理现象。
