Cohen Gali, Steinberg David M, Keinan-Boker Lital, Shaked Or, Goshen Abigail, Shimony Tal, Shohat Tamar, Gerber Yariv
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Stanley Steyer Institute for Cancer Epidemiology and Research, Tel Aviv University, Tel Aviv, Israel.
Mayo Clin Proc Innov Qual Outcomes. 2020 Apr 6;4(2):115-125. doi: 10.1016/j.mayocpiqo.2019.11.005. eCollection 2020 Apr.
To examine the association between leisure-time physical activity (LTPA) and long-term cancer risk in a nationwide cohort of older adults.
The cohort comprised participants of a national survey conducted between July 2005 and December 2006, constituting a random sample of Israeli community-dwelling adults aged 65 years or older. Based on self-reported LTPA habits, participants were classified as sufficiently active, insufficiently active, or inactive according to published guidelines. Cancer diagnosis was assessed via the Israeli National Cancer Registry through September 2015. Inverse probability weighted hazard ratios for incident cancer, based on propensity score, were estimated for LTPA categories.
Analysis included 1542 participants with no history of cancer at baseline (median [25th-75th percentile] age, 73 years [69-78 years]; 826 [53.6%] women). Inactive participants (n=641 [41.6%]) were more likely to be female, of lower socioeconomic status, and with higher body mass index and poorer perceived health compared with their insufficiently active (n=443 [28.7%]) and sufficiently active (n=458 [29.7%]) counterparts. In the propensity score-weighted synthetic sample, the distribution of measured baseline covariates was similar across LTPA categories. Over a median follow-up of 9 years, 254 new cancer cases (16.5%) were diagnosed. Leisure-time physical activity was inversely associated with incident cancer, with adjusted hazard ratios (95% CIs) of 0.66 (0.46-0.93) in insufficiently active and 0.59 (0.42-0.82) in sufficiently active participants compared with inactive individuals ( value for trend = .002).
Among older adults, engaging in LTPA, even at lower levels than officially recommended, may have a beneficial effect on primary prevention of cancer.
在全国范围内的老年人群队列中，研究休闲时间体力活动（LTPA）与长期癌症风险之间的关联。
该队列包括2005年7月至2006年12月期间进行的一项全国性调查的参与者，构成了以色列65岁及以上社区居住成年人的随机样本。根据自我报告的LTPA习惯，按照已发表的指南，参与者被分类为活动量充足、活动量不足或不活动。通过以色列国家癌症登记处评估截至2015年9月的癌症诊断情况。基于倾向评分，估计LTPA类别中癌症发病的逆概率加权风险比。
分析纳入了1542名基线时无癌症病史的参与者（年龄中位数[第25 - 75百分位数]为73岁[69 - 78岁]；826名[53.6%]为女性）。与活动量不足（n = 443 [28.7%]）和活动量充足（n = 458 [29.7%]）的参与者相比，不活动的参与者（n = 641 [41.6%]）更可能为女性，社会经济地位较低，体重指数较高，且自我感觉健康状况较差。在倾向评分加权的合成样本中，各LTPA类别中测量的基线协变量分布相似。在中位随访9年期间，诊断出254例新癌症病例（16.5%）。休闲时间体力活动与癌症发病呈负相关，与不活动的个体相比，活动量不足的参与者调整后的风险比（95%置信区间）为0.66（0.46 - 93），活动量充足的参与者为0.59（0.42 - 0.82）（趋势 值 = 0.002）。
在老年人中，即使进行低于官方推荐水平的LTPA，也可能对癌症的一级预防产生有益影响。
