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与打算在医院分娩的低产科风险女性相比,打算在家分娩的女性的孕产妇结局和分娩干预措施:一项系统评价和荟萃分析。

Maternal outcomes and birth interventions among women who begin labour intending to give birth at home compared to women of low obstetrical risk who intend to give birth in hospital: A systematic review and meta-analyses.

作者信息

Reitsma Angela, Simioni Julia, Brunton Ginny, Kaufman Karyn, Hutton Eileen K

机构信息

McMaster Midwifery Research Centre, McMaster University, Hamilton, Ontario, Canada.

Faculty of Health Sciences, Ontario Tech University, Oshawa Canada.

出版信息

EClinicalMedicine. 2020 Apr 5;21:100319. doi: 10.1016/j.eclinm.2020.100319. eCollection 2020 Apr.

Abstract

BACKGROUND

We previously concluded that risk of stillbirth, neonatal mortality or morbidity is not different whether birth is intended at home or hospital. Here, we compare the occurrence of birth interventions and maternal outcomes among low-risk women who begin labour intending to birth at home compared to women intending to birth in hospital.

METHODS

We used our registered protocol (PROSPERO, http://www.crd.york.ac.uk, No.CRD42013004046) and searched five databases from 1990-2018. Using R, we obtained pooled estimates of effect (accounting for study design, study setting and parity).

FINDINGS

16 studies provided data from ~500,000 intended home births for the meta-analyses. There were no reported maternal deaths. When controlling for parity in well-integrated settings we found women intending to give birth at home compared to hospital were less likely to experience: caesarean section OR 0.58(0.44,0.77); operative vaginal birth OR 0.42(0.23,0.76); epidural analgesia OR 0.30(0.24,0.38); episiotomy OR 0.45(0.28,0.73); 3rd or 4th degree tear OR 0.57(0.43,0.75); oxytocin augmentation OR 0.37(0.26,0.51) and maternal infection OR 0.23(0.15,0.35). Pooled results for postpartum haemorrhage showed women intending home births were either less likely or did not differ from those intending hospital birth [OR 0.66(0.54,0.80) and RR 1.30(0.79,2.13) from 2 studies that could not be pooled with the others]. Similar results were found when data were stratified by parity and by degree of integration into health systems.

INTERPRETATION

Among low-risk women, those intending to birth at home experienced fewer birth interventions and untoward maternal outcomes. These findings along with earlier work reporting neonatal outcomes inform families, health care providers and policy makers around the safety of intended home births.

FUNDING

Partial funding: Association of Ontario Midwives open peer reviewed grant.

摘要

背景

我们之前得出结论,无论计划在家分娩还是在医院分娩,死产、新生儿死亡率或发病率的风险并无差异。在此,我们比较了计划在家分娩的低风险女性与计划在医院分娩的女性之间分娩干预措施的发生率及产妇结局。

方法

我们使用已注册的方案(国际前瞻性系统评价注册库,http://www.crd.york.ac.uk,编号:CRD42013004046),检索了1990年至2018年的五个数据库。使用R软件,我们获得了效应的合并估计值(考虑了研究设计、研究地点和产次)。

结果

16项研究为荟萃分析提供了约500,000例计划在家分娩的数据。未报告产妇死亡情况。在整合良好的环境中控制产次后,我们发现计划在家分娩的女性与在医院分娩的女性相比,经历以下情况的可能性较小:剖宫产,比值比为0.58(0.44,0.77);阴道助产,比值比为0.42(0.23,0.76);硬膜外镇痛,比值比为0.30(0.24,0.38);会阴切开术,比值比为0.45(0.28,0.73);三度或四度会阴裂伤,比值比为0.57(0.43,0.75);缩宫素加强宫缩,比值比为0.37(0.26,0.51);产妇感染,比值比为0.23(0.15,0.35)。产后出血的合并结果显示,计划在家分娩的女性发生产后出血的可能性较小或与计划在医院分娩的女性无差异[两项无法与其他研究合并的研究得出的比值比为0.66(0.54,0.80),相对危险度为1.30(0.79,2.13)]。按产次和卫生系统整合程度分层的数据也得出了类似结果。

解读

在低风险女性中,计划在家分娩的女性经历的分娩干预措施和不良产妇结局较少。这些发现以及早期报告新生儿结局的研究,为家庭、医疗保健提供者和政策制定者提供了有关计划在家分娩安全性的信息。

资金来源

部分资金:安大略省助产士协会开放同行评审资助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77b8/7136633/e60ef96a38c3/gr1.jpg

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