Cui Mei-Na, Zhong Ling-Yun, Zhang Da-Yong, Yang Ming
Jiangxi University of Traditional Chinese Medicine Nanchang 330004, China.
Sichuan Neautus Traditional Chinese Herb Limited Company Sichuan 611731, China.
Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(6):1304-1310. doi: 10.19540/j.cnki.cjcmm.20200207.305.
In the clinical practice of traditional Chinese medicine, Pinelliae Rhizoma is a commonly used traditional Chinese medicinal material, with a very important medicinal value, but its raw products have certain toxicity. According to the basic theory of traditional Chinese medicine, after Pinelliae Rhizoma is processed, its toxic and side effects can be reduced, there by ensuring its medication safety in clinic. Based on the processing characteristics of Pinelliae Rhizoma replication method, this article discusses the changes before and after processing of Pinelliae Rhizoma with multiple materials and multiple processes. This method does not have a unified process. One or more materials are added, and various processes, such as dipping, soaking, bleaching, or steaming, cooking or combined methods are adopted. Then, Pinelliae Rhizoma is repeatedly processed to meet the specified quality requirements. By different processing methods, the efficacy changes accordingly, and Pinelliae Rhizoma can be used for the treatment of different diseases. The article starts in the two directions of multi-materials and multi-processes, and summarizes the effects of multi-materials or multi-processes on the chemical composition and efficacy, as well as the processing mechanism of reducing toxicity and increasing efficiency, in the expectation of reducing the toxicity and enhancing the efficacy of Pinelliae Rhizoma. The medicinal scope provides a reference and theoretical basis for further studies on the processing mechanism. An in-depth study is conducted to make Pinelliae Rhizoma more safe and effective in clinic application, and ensure its clinical efficacy. It will provide reference for future studies on quality control, active ingredients and new drug development of the processing of pinellia slices. It has laid a scientific foundation for exploring the best processing techno-logy, and provided a theoretical basis for solving the production problems of processed Pinelliae Rhizoma products, so as to improve the production efficiency and the quality of medicines.
在中医临床实践中，半夏是常用的中药材，具有非常重要的药用价值，但其生品有一定毒性。根据中医基础理论，半夏经过炮制后，其毒副作用可降低，从而保证其临床用药安全。基于半夏复制法的炮制特点，本文探讨了半夏采用多种辅料、多种工艺炮制前后的变化。该法没有统一的工艺流程，加入一种或多种辅料，并采用浸渍、浸泡、漂、蒸、煮或多种方法相结合，对半夏反复炮制以达到规定的质量要求。通过不同的炮制方法，其功效相应改变，半夏可用于治疗不同病症。文章从多辅料、多工艺两个方向入手，总结多辅料或多工艺对半夏化学成分及功效的影响，以及其减毒增效的炮制机理，以期降低半夏毒性，增强其药效，为进一步研究其炮制机理的药用范围提供参考和理论依据。进行深入研究以使半夏在临床应用中更加安全有效，确保其临床疗效。为今后半夏饮片炮制的质量控制、有效成分及新药开发等研究提供参考。为探索最佳炮制工艺奠定了科学基础，为解决半夏炮制产品的生产问题提供了理论依据，从而提高生产效率和药品质量。
