Neshige R, Lüders H, Friedman L, Shibasaki H
Department of Neurology, Cleveland Clinic Foundation, OH 44195-5221.
Ann Neurol. 1988 Sep;24(3):439-45. doi: 10.1002/ana.410240313.
A patient with intractable epilepsy secondary to a brain tumor was evaluated with a chronically implanted array of 64 stainless-steel subdural electrodes covering the perirolandic area. Cortical potentials associated with voluntary, self-paced middle-finger extension were recorded simultaneously from subdural and scalp electrodes using a computer-assisted method for averaging movement-related potential (MRP) in relation to electromyographic (EMG) onset. A high-amplitude negative potential, Bereitschaftspotential/negative slope (BP/NS'), preceding the onset of the EMG activity by more than 1 sec was recorded in an extremely localized fashion exclusively from electrodes placed in the precentral hand motor area as well as in the more medial part of the somatosensory hand area. These results suggest that the hand motor and sensory areas have an essential participation in the generation of MRPs and, therefore, also in the preparation of voluntary finger movements.
一名继发于脑肿瘤的难治性癫痫患者，使用覆盖中央前回手部区域的64个不锈钢硬膜下电极的长期植入阵列进行评估。使用计算机辅助方法，在肌电图（EMG）开始时平均运动相关电位（MRP），同时从硬膜下电极和头皮电极记录与自愿、自定节奏的中指伸展相关的皮质电位。在肌电活动开始前1秒以上记录到一个高振幅负电位，即准备电位/负斜率（BP/NS'），该电位仅以极其局限的方式从位于中央前回手部运动区以及体感手部区域更内侧部分的电极记录到。这些结果表明，手部运动和感觉区域在MRP的产生中起着重要作用，因此，在自愿手指运动的准备中也起着重要作用。
