CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
J Nat Prod. 2020 Apr 24;83(4):1258-1264. doi: 10.1021/acs.jnatprod.0c00050. Epub 2020 Apr 13.
Seven unusual new ene-yne hydroquinones (-, -), including three rare glycosylated derivatives named pestalotioquinosides A-C (-), were obtained from the marine-derived strain SCSIO41403 of the fungus . Their structures including absolute configurations were elucidated by spectroscopic analysis and induced electronic circular dichroism experiments. In silico molecular docking and surface plasmon resonance studies showed that pestalotioquinoside C () could act as a liver X receptor alpha (LXRα) modulator. Further study showed that LXR target gene was significantly upregulated by , which revealed as a potential LXRα agonist.
从海洋来源真菌 SCSIO41403 中分离得到了 7 种新型的烯炔类对苯二酚（-，-），包括 3 种罕见的糖基化衍生物，命名为 pestalotioquinosides A-C（-）。通过光谱分析和诱导电子圆二色性实验确定了它们的结构，包括绝对构型。基于计算机的分子对接和表面等离子体共振研究表明，pestalotioquinoside C（-）可以作为肝 X 受体α（LXRα）调节剂。进一步的研究表明，-显著上调了 LXR 靶基因 ，表明其为潜在的 LXRα激动剂。
