CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Mar Drugs. 2024 Aug 26;22(9):384. doi: 10.3390/md22090384.
Three new polyketides, including three ester derivatives (, , and ) and a new natural product, which was a benzoquinone derivative, embelin A (), together with nine known ones ( and -), were isolated from the mangrove-derived fungus sp. SCSIO 41411. Their structures were determined by detailed NMR and MS spectroscopic analyses. The X-ray single-crystal diffraction analysis of was described for the first time. Compound displayed obvious inhibition against PDE4 with an inhibitory ratio of 40.78% at 10 μM. Compound showed DPPH radical scavenging activity, with an EC of 16.21 µg/mL, compared to the positive control (ascorbic acid, EC, 11.22 µg/mL). Furthermore, compound exhibited cytotoxicity against PC-3 and LNCaP with IC values of 18.69 and 31.62 µM, respectively.
从红树林来源的真菌 sp. SCSIO 41411 中分离得到了三个新的聚酮化合物，包括三个酯衍生物（、和）和一个新的天然产物，即苯醌衍生物 embelin A（），以及九个已知化合物（和-）。通过详细的 NMR 和 MS 光谱分析确定了它们的结构。首次对进行了 X 射线单晶衍射分析。化合物在 10 μM 时对 PDE4 的抑制率为 40.78%，显示出明显的抑制作用。化合物表现出 DPPH 自由基清除活性，EC 为 16.21 µg/mL，与阳性对照（抗坏血酸，EC 为 11.22 µg/mL）相比。此外，化合物对 PC-3 和 LNCaP 的细胞毒性分别为 18.69 和 31.62 µM。
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