Green Extraction Team, Avignon University, INRAE, UMR408, F-84000 Avignon, France.
Pennakem Europa, 224 avenue de la Dordogne, F-59944 Dunkerque, France.
Molecules. 2020 Apr 9;25(7):1727. doi: 10.3390/molecules25071727.
The potential of using the bio-based solvent 2-methyloxolane, also known as 2-methyltetrahydrofuran or 2-MeTHF, as an alternative to petroleum solvents such as hexane, was investigated for the extraction of volatile compounds from hop cones ( L.). Lab scale extractions were coupled with in silico prediction of solutes solubility to assess the technical potential of this bio-based solvent. The predictive approach was performed using the simulation software COSMO-RS (conductor like screening model for real solvants) and showed that the 2-methyloxolane is as good as or better than hexane to solubilize the majority of aromas from hop cones. The experimental results indicated that the highest aroma yield was obtained with 2-methyloxolane with 20.2% while -hexane was only able to extract 17.9%. The characterization of aromas extracted by the two solvents showed a similar composition, where lupulone was the main component followed by humulone. No selectivity of the solvents was observed for any of the major analytes. Finally, a sensory analysis was performed on the extracts, showing that both concretes using 2-methyloxolane and hexane have similar olfactory profiles. The results indicate that 2-methyloxolane could be a promising bio-based extraction solvent for hexane substitution.
研究了生物基溶剂 2-甲基四氢呋喃（也称为 2-甲基四氢呋喃或 2-MeTHF）作为石油溶剂（如己烷）替代品，从啤酒花（Humulus lupulus L.）中提取挥发性化合物的潜力。实验室规模的提取与溶质溶解度的计算预测相结合，以评估这种生物基溶剂的技术潜力。该预测方法使用模拟软件 COSMO-RS（用于真实溶剂的导电筛选模型）进行，结果表明 2-甲基四氢呋喃在溶解啤酒花中的大多数香气方面与己烷一样好，甚至更好。实验结果表明，用 2-甲基四氢呋喃提取的香气收率最高，为 20.2%，而己烷只能提取 17.9%。两种溶剂提取的香气的特征表明，组成相似，其中律草酮是主要成分，其次是葎草酮。对于任何主要分析物，溶剂都没有选择性。最后，对提取物进行了感官分析，结果表明，使用 2-甲基四氢呋喃和己烷的两种浸膏具有相似的气味特征。结果表明，2-甲基四氢呋喃可能是一种有前途的生物基提取溶剂，可以替代己烷。
