Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Gynaecology and Obstetrics, St Olav's Hospital, Trondheim, Norway.
Exercise and Nutrition Research Programme, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3000, Australia.
Trends Endocrinol Metab. 2020 Aug;31(8):561-569. doi: 10.1016/j.tem.2020.03.002. Epub 2020 Apr 10.
About one-third of women of reproductive age are obese, predisposing both mother and baby to unfavourable pregnancy outcomes and initiating an intergenerational cycle of chronic metabolic disorders. Here we summarise recent research on the influence of maternal metabolic health on offspring susceptibility to future cardiometabolic diseases. Current primary lifestyle approaches (i.e., diet and exercise interventions) to halt the succession of inherited and epigenetic metabolic abnormalities have met with limited success due to late implementation, poor adherence, and/or generic guidelines. In our opinion, such interventions must commence prior to conception to improve both maternal and child health outcomes, with new approaches urgently needed to increase adherence to primary lifestyle changes among reproductive-age women.
大约三分之一的育龄妇女肥胖，这使母亲和婴儿都面临不良的妊娠结局，并引发了代际慢性代谢紊乱的循环。在这里，我们总结了最近关于母体代谢健康对后代未来患心血管代谢疾病易感性的影响的研究。目前主要的生活方式方法（即饮食和运动干预）由于实施时间晚、坚持率低和/或通用指南，已经在一定程度上阻止了遗传和表观遗传代谢异常的延续，但收效甚微。我们认为，这种干预措施必须在受孕前开始，以改善母婴健康结局，迫切需要新的方法来提高育龄妇女对主要生活方式改变的坚持率。
