Kassam-Adams Nancy, Kenardy Justin A, Delahanty Douglas L, Marsac Meghan L, Meiser-Stedman Richard, Nixon Reginald D V, Landolt Markus A, Palmieri Patrick A
Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Psychology, University of Queensland, Brisbane, Australia.
Eur J Psychotraumatol. 2020 Mar 10;11(1):1729025. doi: 10.1080/20008198.2020.1729025. eCollection 2020.
: Studies that identify children after acute trauma and prospectively track risk/protective factors and trauma responses over time are resource-intensive; small sample sizes often limit power and generalizability. The Prospective studies of Acute Child Trauma and Recovery (PACT/R) Data Archive was created to facilitate more robust integrative cross-study data analyses. : To (a) describe creation of this research resource, including harmonization of key variables; (b) describe key study- and participant-level variables; and (c) examine retention to follow-up across studies. : For the first 30 studies in the Archive, we described study-level (design factors, retention rates) and participant-level (demographic, event, traumatic stress) variables. We used Chi square or ANOVA to examine study- and participant-level variables potentially associated with retention. : These 30 prospective studies (N per study = 50 to 568; overall N = 5499) conducted by 15 research teams in 5 countries enrolled children exposed to injury (46%), disaster (24%), violence (13%), traffic accidents (10%), or other acute events. Participants were school-age or adolescent (97%), 60% were male, and approximately half were of minority ethnicity. Using harmonized data from 22 measures, 24% reported significant traumatic stress ≥1 month post-event. Other commonly assessed outcomes included depression (19 studies), internalizing/externalizing symptoms (19), and parent mental health (19). Studies involved 2 to 5 research assessments; 80% of participants were retained for ≥2 assessments. At the study level, greater retention was associated with more planned assessments. At the participant level, adolescents, minority youth, and those of lower socioeconomic status had lower retention rates. : This project demonstrates the feasibility and value of bringing together traumatic stress research data and making it available for re-use. As an ongoing research resource, the Archive can promote 'FAIR' data practices and facilitate integrated analyses to advance understanding of child traumatic stress.
识别急性创伤后的儿童并前瞻性地跟踪风险/保护因素及创伤反应随时间变化的研究资源密集；小样本量往往会限制效能和普遍性。急性儿童创伤与恢复前瞻性研究（PACT/R）数据存档库的创建是为了促进更有力的综合跨研究数据分析。
（a）描述该研究资源的创建，包括关键变量的协调；（b）描述关键的研究和参与者层面的变量；（c）检查各研究的随访保留情况。
对于存档库中的前30项研究，我们描述了研究层面（设计因素、保留率）和参与者层面（人口统计学、事件、创伤应激）的变量。我们使用卡方检验或方差分析来检查可能与保留情况相关的研究和参与者层面的变量。
这30项前瞻性研究（每项研究的样本量N = 50至568；总体N = 5499）由5个国家的15个研究团队进行，纳入了遭受伤害（46%）、灾难（24%）、暴力（13%）、交通事故（10%）或其他急性事件的儿童。参与者为学龄儿童或青少年（97%），60%为男性，约一半为少数族裔。使用来自22项测量的协调数据，24%的人报告在事件发生后≥1个月有显著的创伤应激。其他常见评估结果包括抑郁（19项研究）、内化/外化症状（19项）和父母心理健康（19项）。研究涉及2至5次研究评估；80%的参与者被保留进行≥2次评估。在研究层面，更高的保留率与更多的计划评估相关。在参与者层面，青少年、少数族裔青年和社会经济地位较低的人保留率较低。
该项目证明了整合创伤应激研究数据并使其可供重新使用的可行性和价值。作为一个持续的研究资源，存档库可以促进“FAIR”数据实践，并便于进行综合分析以增进对儿童创伤应激的理解。
