Shanghai Applied Radiation Institute, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China.
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.
Adv Exp Med Biol. 2020;1229:65-78. doi: 10.1007/978-981-15-1671-9_3.
Cardiovascular disease is characterized by its highest morbidity and mortality. One of the main pathological basis of this disease is the dysregulation of gene expression. Non-coding RNA (ncRNA) is a kind of functional RNA, which is transcript from DNA but not translated into proteins. More and more studies have established the important roles of ncRNAs, including transcription, RNA maturation, translation, protein degradation, and their involvement in the pathogenesis of diseases such as cancer and cardiovascular diseases. This chapter will focus on the biological functions of ncRNAs and their advances in cardiovascular disease. With the development of sequencing and computer technology, more and more databases can be easily obtained on the internet. In another part of this chapter, we will summarize some commonly used non-coding RNA databases, which can be easily and quickly used for relevant research.
心血管疾病的发病率和死亡率最高。这种疾病的主要病理基础之一是基因表达失调。非编码 RNA（ncRNA）是一种功能 RNA，它由 DNA 转录而来，但不翻译成蛋白质。越来越多的研究已经确立了 ncRNA 的重要作用，包括转录、RNA 成熟、翻译、蛋白质降解，以及它们在癌症和心血管疾病等疾病发病机制中的参与。本章将重点介绍 ncRNA 的生物学功能及其在心血管疾病中的进展。随着测序和计算机技术的发展，互联网上可以轻松获得更多的数据库。在本章的另一部分，我们将总结一些常用的非编码 RNA 数据库，这些数据库可以方便、快速地用于相关研究。
