County Clinical Emergency Hospital of Brasov Romania, 500326 Brașov, Romania.
Department of Vascular Surgery, Second Surgical Clinic, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
Int J Mol Sci. 2022 Mar 1;23(5):2728. doi: 10.3390/ijms23052728.
Recent knowledge concerning the role of non-coding RNAs (ncRNAs) in myocardial ischemia/reperfusion (I/R) injury provides new insight into their possible roles as specific biomarkers for early diagnosis, prognosis, and treatment. MicroRNAs (miRNAs) have fewer than 200 nucleotides, while long ncRNAs (lncRNAs) have more than 200 nucleotides. The three types of ncRNAs (miRNAs, lncRNAs, and circRNAs) act as signaling molecules strongly involved in cardiovascular disorders (CVD). I/R injury of the heart is the main CVD correlated with acute myocardial infarction (AMI), cardiac surgery, and transplantation. The expression levels of many ncRNAs and miRNAs are highly modified in the plasma of MI patients, and thus they have the potential to diagnose and treat MI. Cardiomyocyte and endothelial cell death is the major trigger for myocardial ischemia-reperfusion syndrome (MIRS). The cardioprotective effect of inflammasome activation in MIRS and the therapeutics targeting the reparative response could prevent progressive post-infarction heart failure. Moreover, the pharmacological and genetic modulation of these ncRNAs has the therapeutic potential to improve clinical outcomes in AMI patients.
最近关于非编码 RNA（ncRNAs）在心肌缺血/再灌注（I/R）损伤中的作用的知识为它们作为早期诊断、预后和治疗的特定生物标志物的可能作用提供了新的见解。微小 RNA（miRNA）的长度少于 200 个核苷酸，而长链非编码 RNA（lncRNA）的长度大于 200 个核苷酸。三种 ncRNA（miRNA、lncRNA 和 circRNA）作为信号分子强烈参与心血管疾病（CVD）。心脏的 I/R 损伤是与急性心肌梗死（AMI）、心脏手术和移植相关的主要 CVD。许多 ncRNA 和 miRNA 的表达水平在 MI 患者的血浆中高度改变，因此它们具有诊断和治疗 MI 的潜力。心肌细胞和内皮细胞死亡是心肌缺血再灌注综合征（MIRS）的主要触发因素。MIRS 中炎症小体激活的心脏保护作用和针对修复反应的治疗方法可以预防梗死后心力衰竭的进展。此外，这些 ncRNA 的药理学和遗传学调节具有改善 AMI 患者临床结局的治疗潜力。
