College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Key Laboratory of Cardiovascular Medicine Research, Harbin Medical University, Ministry of Education, China.
Brief Bioinform. 2019 Jan 18;20(1):66-76. doi: 10.1093/bib/bbx095.
Cardiovascular diseases (CVDs) continue to be a major cause of morbidity and mortality, and non-coding RNAs (ncRNAs) play critical roles in CVDs. With the recent emergence of high-throughput technologies, including small RNA sequencing, investigations of CVDs have been transformed from candidate-based studies into genome-wide undertakings, and a number of ncRNAs in CVDs were discovered in various studies. A comprehensive review of these ncRNAs would be highly valuable for researchers to get a complete picture of the ncRNAs in CVD. To address these knowledge gaps and clinical needs, in this review, we first discussed dysregulated ncRNAs and their critical roles in cardiovascular development and related diseases. Moreover, we reviewed >28 561 published papers and documented the ncRNA-CVD association benchmarking data sets to summarize the principles of ncRNA regulation in CVDs. This data set included 13 249 curated relationships between 9503 ncRNAs and 139 CVDs in 12 species. Based on this comprehensive resource, we summarized the regulatory principles of dysregulated ncRNAs in CVDs, including the complex associations between ncRNA and CVDs, tissue specificity and ncRNA synergistic regulation. The highlighted principles are that CVD microRNAs (miRNAs) are highly expressed in heart tissue and that they play central roles in miRNA-miRNA functional synergistic network. In addition, CVD-related miRNAs are close to one another in the functional network, indicating the modular characteristic features of CVD miRNAs. We believe that the regulatory principles summarized here will further contribute to our understanding of ncRNA function and dysregulation mechanisms in CVDs.
心血管疾病（CVDs）仍然是发病率和死亡率的主要原因，非编码 RNA（ncRNAs）在 CVDs 中发挥着关键作用。随着高通量技术的出现，包括小 RNA 测序，CVDs 的研究已经从基于候选的研究转变为全基因组的研究，在各种研究中发现了许多与 CVDs 相关的 ncRNAs。对这些 ncRNAs 的全面综述对于研究人员全面了解 CVDs 中的 ncRNAs 将非常有价值。为了解决这些知识空白和临床需求，在本综述中，我们首先讨论了失调的 ncRNAs 及其在心血管发育和相关疾病中的关键作用。此外，我们回顾了超过 28561 篇已发表的论文，并记录了 ncRNA-CVD 关联基准数据集，以总结 ncRNA 在 CVDs 中的调节原理。该数据集包括 13249 个与 12 个物种中的 9503 个 ncRNA 和 139 种 CVD 之间的已证实关系。基于这个全面的资源，我们总结了失调的 ncRNAs 在 CVDs 中的调节原理，包括 ncRNA 与 CVDs 之间的复杂关联、组织特异性和 ncRNA 的协同调节。突出的原则是 CVD 微小 RNA（miRNAs）在心脏组织中高度表达，并且在 miRNA-miRNA 功能协同网络中发挥核心作用。此外，与 CVD 相关的 miRNAs 在功能网络中彼此接近，表明 CVD miRNAs 具有模块化特征。我们相信，这里总结的调节原理将进一步促进我们对 ncRNA 在 CVDs 中的功能和失调机制的理解。
