I, 3. 肠道神经系统与感染性腹泻。
I, 3. The enteric nervous system and infectious diarrhea.
作者信息
Lundgren Ove, Svensson Lennart
机构信息
Department of Physiology, Sahlgrenska Academy, Göteborg University, Box 432, S-405 30, Göteborg, Sweden.
Department of Virology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden.
出版信息
Perspect Med Virol. 2003;9:51-67. doi: 10.1016/S0168-7069(03)09004-9. Epub 2004 Sep 14.
This chapter discusses the background knowledge about the enteric nervous system (ENS) as well as the role of ENS in secretory states of the small intestine. The chapter describes the anatomy and physiology of the ENS. A description of the experimental evidence for the involvement of ENS in secretory states of the gut, primarily in cholera toxin-induced secretion that is the most thoroughly investigated secretory state, is presented in the chapter. The chapter focuses on the involvement of ENS in rotavirus (RV) diarrhea. The involvement of the ENS in diarrhea pathophysiology opens up new potential sites of action for drugs in the treatment of intestinal secretory states. The chapter concludes with a discussion of the sites of action for the pharmacological treatment of diarrhea.
本章讨论了关于肠神经系统（ENS）的背景知识以及ENS在小肠分泌状态中的作用。本章描述了ENS的解剖学和生理学。本章还介绍了ENS参与肠道分泌状态的实验证据，主要是在霍乱毒素诱导的分泌方面，这是研究最为深入的分泌状态。本章重点关注ENS在轮状病毒（RV）腹泻中的作用。ENS参与腹泻病理生理学为治疗肠道分泌状态的药物开辟了新的潜在作用位点。本章最后讨论了腹泻药物治疗的作用位点。
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