I, 2. 肠道与病毒性腹泻相关的生理学和病理生理学。
I, 2. Physiology and pathophysiology of the gut in relation to viral diarrhea.
作者信息
Michelangeli Fabián, Ruiz Marie Christine
机构信息
Laboratorio de Fisiología Gastrointestinal, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC) Caracas, Venezuela.
出版信息
Perspect Med Virol. 2003;9:23-50. doi: 10.1016/S0168-7069(03)09003-7. Epub 2004 Sep 14.
Abstract
Many advances have been made in the understanding of intestinal electrolyte transport from the molecular to the whole-tissue level. This chapter discusses the molecular mechanisms of intestinal epithelial ion transport processes, as well as the intra- and extracellular factors involved in their regulation, as a framework for the understanding of virus-induced gastroenteritis. Based on the present knowledge of the effects of rotavirus (RV) infection on the physiology of the intestine at different levels of organization, a working model for the pathogenesis of RV diarrhea is presented in the chapter. The understanding of the pathogenic processes of viral diarrheas may serve as the basis for a rational approach in the design of novel therapeutic strategies and the search for new antiviral drugs.
摘要
在从分子水平到全组织水平理解肠道电解质转运方面已经取得了许多进展。本章讨论肠道上皮离子转运过程的分子机制，以及参与其调节的细胞内和细胞外因素，作为理解病毒感染性胃肠炎的框架。基于目前对轮状病毒（RV）感染在不同组织水平对肠道生理学影响的认识，本章提出了RV腹泻发病机制的工作模型。对病毒性腹泻致病过程的理解可为设计新型治疗策略和寻找新抗病毒药物的合理方法提供依据。
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