• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
I, 2. Physiology and pathophysiology of the gut in relation to viral diarrhea.I, 2. 肠道与病毒性腹泻相关的生理学和病理生理学。
Perspect Med Virol. 2003;9:23-50. doi: 10.1016/S0168-7069(03)09003-7. Epub 2004 Sep 14.
2
Resveratrol dimer trans-ε-viniferin prevents rotaviral diarrhea in mice by inhibition of the intestinal calcium-activated chloride channel.白藜芦醇二聚体反式-ε-viniferin 通过抑制肠道钙激活氯离子通道预防轮状病毒腹泻。
Pharmacol Res. 2018 Mar;129:453-461. doi: 10.1016/j.phrs.2017.11.016. Epub 2017 Nov 14.
3
The cystic fibrosis transmembrane conductance regulator attenuates the endogenous Ca2+ activated Cl- conductance of Xenopus oocytes.囊性纤维化跨膜传导调节因子减弱非洲爪蟾卵母细胞的内源性Ca2+激活的Cl-传导。
Pflugers Arch. 1997 Dec;435(1):178-81. doi: 10.1007/s004240050498.
4
C-type natriuretic peptide increases chloride permeability in normal and cystic fibrosis airway cells.C型利钠肽增加正常和囊性纤维化气道细胞的氯离子通透性。
Am J Respir Cell Mol Biol. 1997 Apr;16(4):464-70. doi: 10.1165/ajrcmb.16.4.9115758.
5
Guanylate cyclase 2C agonism corrects CFTR mutants.鸟苷酸环化酶 2C 激动剂纠正 CFTR 突变体。
JCI Insight. 2017 Oct 5;2(19):93686. doi: 10.1172/jci.insight.93686.
6
Expression of delta F508 cystic fibrosis transmembrane conductance regulator protein and related chloride transport properties in the gallbladder epithelium from cystic fibrosis patients.囊性纤维化患者胆囊上皮中δF508囊性纤维化跨膜传导调节蛋白的表达及相关氯离子转运特性
Hepatology. 1999 Jun;29(6):1624-34. doi: 10.1002/hep.510290634.
7
Plumbagin Prevents Secretory Diarrhea by Inhibiting CaCC and CFTR Channel Activities.白花丹醌通过抑制钙激活氯离子通道（CaCC）和囊性纤维化跨膜传导调节因子（CFTR）通道活性来预防分泌性腹泻。
Front Pharmacol. 2019 Oct 9;10:1181. doi: 10.3389/fphar.2019.01181. eCollection 2019.
8
CFTR-NHERF2-LPA₂ Complex in the Airway and Gut Epithelia.气道和肠道上皮中的 CFTR-NHERF2-LPA₂ 复合物。
Int J Mol Sci. 2017 Sep 4;18(9):1896. doi: 10.3390/ijms18091896.
9
Antisense oligodeoxynucleotide to the cystic fibrosis transmembrane conductance regulator inhibits cyclic AMP-activated but not calcium-activated cell volume reduction in a human pancreatic duct cell line.针对囊性纤维化跨膜传导调节因子的反义寡脱氧核苷酸抑制人胰腺导管细胞系中由环磷酸腺苷激活而非钙激活的细胞容积减小。
J Clin Invest. 1993 Mar;91(3):1253-7. doi: 10.1172/JCI116289.
10
Drug-induced secretory diarrhea: A role for CFTR.药物性分泌性腹泻：囊性纤维化跨膜传导调节因子的作用。
Pharmacol Res. 2015 Dec;102:107-112. doi: 10.1016/j.phrs.2015.08.024. Epub 2015 Sep 30.

引用本文的文献

1
LMWP (S3-3) from the Larvae of Alleviate D-IBS by Adjusting the Gut Microbiota.低分子肝素（S3-3）通过调节肠道微生物群缓解 D-IBS。
Molecules. 2022 Jul 15;27(14):4517. doi: 10.3390/molecules27144517.
2
Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation.肠道对病毒入侵的易感性：饮食、微生物群和肠神经系统对黏膜屏障保护的作用。
Int J Mol Sci. 2021 Apr 29;22(9):4734. doi: 10.3390/ijms22094734.
3
Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea.轮状病毒感染在腹泻发作时增加肠道蠕动但不增加通透性。
J Virol. 2014 Mar;88(6):3161-9. doi: 10.1128/JVI.02927-13. Epub 2013 Dec 26.
4
Expression of nonstructural rotavirus protein NSP4 mimics Ca2+ homeostasis changes induced by rotavirus infection in cultured cells.轮状病毒非结构蛋白NSP4的表达模拟了轮状病毒感染在培养细胞中诱导的钙离子稳态变化。
J Virol. 2008 Nov;82(22):11331-43. doi: 10.1128/JVI.00577-08. Epub 2008 Sep 10.
5
How do the rotavirus NSP4 and bacterial enterotoxins lead differently to diarrhea?轮状病毒NSP4和细菌肠毒素导致腹泻的方式有何不同？
Virol J. 2007 Mar 21;4:31. doi: 10.1186/1743-422X-4-31.
6
Rotavirus infection is not associated with small intestinal fluid secretion in the adult mouse.轮状病毒感染与成年小鼠的小肠液分泌无关。
J Virol. 2006 Nov;80(22):11355-61. doi: 10.1128/JVI.00152-06. Epub 2006 Aug 30.
7
Pathogenesis of intestinal and systemic rotavirus infection.肠道和全身性轮状病毒感染的发病机制。
J Virol. 2004 Oct;78(19):10213-20. doi: 10.1128/JVI.78.19.10213-10220.2004.

本文引用的文献

1
Simultaneous measurement and imaging of intracellular Ca(2+) and H(+) transport in isolated rabbit gastric glands.在分离的兔胃腺中同时测量和成像细胞内钙离子（Ca(2+)）和氢离子（H(+)）转运
J Physiol. 2001 Dec 15;537(Pt 3):735-45. doi: 10.1111/j.1469-7793.2001.00735.x.
2
Pathogenesis of rotavirus diarrhea.轮状病毒腹泻的发病机制。
Microbes Infect. 2001 Nov;3(13):1145-56. doi: 10.1016/s1286-4579(01)01475-7.
3
Evidence of amiloride-sensitive fluid absorption in rat descending colonic crypts from fluorescence recovery of FITC-labelled dextran after photobleaching.光漂白后FITC标记葡聚糖荧光恢复显示大鼠降结肠隐窝中存在氨氯地平敏感的液体吸收证据。
J Physiol. 2001 Oct 15;536(Pt 2):541-53. doi: 10.1111/j.1469-7793.2001.0541c.xd.
4
Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum.一种在十二指肠和空肠中大量表达的新型水通道蛋白（AQP10）的克隆。
Biochem Biophys Res Commun. 2001 Oct 5;287(4):814-9. doi: 10.1006/bbrc.2001.5661.
5
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VIII. Pathological consequences of rotavirus infection and its enterotoxin.微生物与微生物毒素：微生物 - 黏膜相互作用的范例。VIII. 轮状病毒感染及其肠毒素的病理后果。
Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G303-10. doi: 10.1152/ajpgi.2001.281.2.G303.
6
Pathogenesis of rotavirus gastroenteritis.轮状病毒胃肠炎的发病机制。
Novartis Found Symp. 2001;238:82-96; discussion 96-100. doi: 10.1002/0470846534.ch6.
7
Gastroenteritis viruses: an overview.肠胃炎病毒：概述
Novartis Found Symp. 2001;238:5-19; discussion 19-25. doi: 10.1002/0470846534.ch2.
8
Early events of rotavirus infection: the search for the receptor(s).轮状病毒感染的早期事件：寻找受体
Novartis Found Symp. 2001;238:47-60; discussion 60-3. doi: 10.1002/0470846534.ch4.
9
Group C rotavirus NSP4 induces diarrhea in neonatal mice.C组轮状病毒NSP4可诱导新生小鼠腹泻。
Arch Virol. 2001;146(4):801-6. doi: 10.1007/s007050170148.
10
A lack of consistent amino acid substitutions in NSP4 between rotaviruses derived from diarrheal and asymptomatically-infected kittens.源自腹泻和无症状感染小猫的轮状病毒之间，NSP4中缺乏一致的氨基酸替换。
Microbiol Immunol. 2001;45(2):173-7. doi: 10.1111/j.1348-0421.2001.tb01277.x.

I, 2. 肠道与病毒性腹泻相关的生理学和病理生理学。

I, 2. Physiology and pathophysiology of the gut in relation to viral diarrhea.

作者信息

Michelangeli Fabián, Ruiz Marie Christine

机构信息

Laboratorio de Fisiología Gastrointestinal, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC) Caracas, Venezuela.

出版信息

Perspect Med Virol. 2003;9:23-50. doi: 10.1016/S0168-7069(03)09003-7. Epub 2004 Sep 14.

DOI:10.1016/S0168-7069(03)09003-7
PMID:32308248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7157931/
Abstract

Many advances have been made in the understanding of intestinal electrolyte transport from the molecular to the whole-tissue level. This chapter discusses the molecular mechanisms of intestinal epithelial ion transport processes, as well as the intra- and extracellular factors involved in their regulation, as a framework for the understanding of virus-induced gastroenteritis. Based on the present knowledge of the effects of rotavirus (RV) infection on the physiology of the intestine at different levels of organization, a working model for the pathogenesis of RV diarrhea is presented in the chapter. The understanding of the pathogenic processes of viral diarrheas may serve as the basis for a rational approach in the design of novel therapeutic strategies and the search for new antiviral drugs.

摘要

在从分子水平到全组织水平理解肠道电解质转运方面已经取得了许多进展。本章讨论肠道上皮离子转运过程的分子机制，以及参与其调节的细胞内和细胞外因素，作为理解病毒感染性胃肠炎的框架。基于目前对轮状病毒（RV）感染在不同组织水平对肠道生理学影响的认识，本章提出了RV腹泻发病机制的工作模型。对病毒性腹泻致病过程的理解可为设计新型治疗策略和寻找新抗病毒药物的合理方法提供依据。