Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil.
Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil.
Int J Environ Res Public Health. 2020 Apr 11;17(8):2622. doi: 10.3390/ijerph17082622.
At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 [33-44], height 175.7 [172.0-180.3]; weight 74.7 [69.3-81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB-) (EIB+ 44.02 [39.56-47.02] and EIB- 47.62 [44.11-51.18] = 0.03). The comparison of plasma levels of IL-1β (EIB+ = 0.296, EIB- = 0.176, EIB+ vs. EIB- baseline = 0.190 immediately after = 0.106), IL-4 (undetectable), IL-6 (EIB+ = 0.003, EIB- ≤ 0.001, EIB+ vs. EIB- baseline = 0.301 immediately after = 0.614), IL-8 (EIB+ = 0.003, EIB- ≤ 0.001, EIB+ vs. EIB- baseline = 0.110 immediately after = 0.453), IL-10 (EIB+ = 0.003, EIB- ≤ 0.001, EIB+ vs. EIB- baseline = 0.424 immediately after = 0.876) and TNF-α (EIB+ = 0.003, EIB- ≤ 0.001, EIB+ vs. EIB- baseline = 0.141 immediately after = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = -0.81, = 0.022), and IL-10 (r = -0.97, ≤ 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB.
目前，尚不清楚哪些运动诱导因素（如肌因子）可以减轻运动引起的肺功能下降的负面影响。在这项研究中，我们旨在评估运动性支气管收缩（EIB）的发生率，并研究肌因子对表现出 EIB 或不表现出 EIB 的马拉松运动员的表现的影响。38 名男性业余马拉松运动员（年龄 38.8 [33-44]，身高 175.7 [172.0-180.3]；体重 74.7 [69.3-81.6]）参加了这项研究，通过肺活量测定试验，发现 EIB 的发生率为 23.6%，与文献相符。EIB 阳性（EIB+）的志愿者与 EIB 阴性（EIB-）的志愿者相比，最大有氧能力较低（EIB+ 44.02 [39.56-47.02]和 EIB- 47.62 [44.11-51.18] = 0.03）。EIB+和 EIB-组的白细胞介素-1β（EIB+ = 0.296，EIB- = 0.176，EIB+与 EIB-基线相比 = 0.190，立即为 = 0.106）、白细胞介素-4（未检出）、白细胞介素-6（EIB+ = 0.003，EIB- ≤ 0.001，EIB+与 EIB-基线相比 = 0.301，立即为 = 0.614）、白细胞介素-8（EIB+ = 0.003，EIB- ≤ 0.001，EIB+与 EIB-基线相比 = 0.110，立即为 = 0.453）、白细胞介素-10（EIB+ = 0.003，EIB- ≤ 0.001，EIB+与 EIB-基线相比 = 0.424，立即为 = 0.876）和肿瘤坏死因子-α（EIB+ = 0.003，EIB- ≤ 0.001，EIB+与 EIB-基线相比 = 0.141，立即为 = 0.898）在马拉松前 24 小时和马拉松后立即的水平相似。然而，马拉松完赛时间与白细胞介素-8（r = -0.81， = 0.022）和白细胞介素-10（r = -0.97， ≤ 0.001）的水平呈负相关。综上所述，首次表明肌因子白细胞介素-8 和白细胞介素-10 与表现出 EIB 的马拉松运动员的表现改善有关。
