从中分离得到一个新的螺环内酯和一个新的苯并吡喃衍生物。

One new spirocyclic lactone and one new benzopyran derivative from .

机构信息

Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Department of Pharmacy, the Central Hospital of Wuhan Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

J Asian Nat Prod Res. 2021 May;23(5):429-435. doi: 10.1080/10286020.2020.1747052. Epub 2020 Apr 15.

DOI:10.1080/10286020.2020.1747052

PMID:32290693

Abstract

One new spirocyclic lactone, terreinlactone C (), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (), were discovered from the fungus . The chemical structures of compounds and were elucidated by detailedly analyzing NMR and HRESIMS data. Compound is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.[Formula: see text].

摘要

从真菌中发现了一种新的螺环内酯 Terreinlactone C () 和一种新的苯并吡喃衍生物 2,2-二甲基-3-羟基色满-6-醛 ()。通过详细分析 NMR 和 HRESIMS 数据，阐明了化合物和的化学结构。化合物是第一个具有 1-氧螺[4.5]癸烷-2-酮环系统的天然产物，并提出了可能的生物发生途径。两种化合物对五种人癌细胞系的细胞毒性活性进行了测试。[公式：见正文]。