Parc Sanitari Sant Joan de Dèu, Sant Boi de Llobregat, Barcelona, Spain; Hospital Universitari Institut Pere Mata of Reus, Medical Research Institute Pere Virgili (IISPV), and Rovira i Virgili University of Tarragona, Spain; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain.
Hospital del Mar Medical Research Institute (IMIM) of Barcelona, Autonomous University of Barcelona, Spain; Centro de Investigación en Red de Salud Mental (CIBERSAM), Spain.
Eur Neuropsychopharmacol. 2020 Jul;36:235-243. doi: 10.1016/j.euroneuro.2020.03.003. Epub 2020 Apr 12.
There is a scarcity of studies investigating the effect of sex on the clinical and treatment characteristics of first-admitted patients with first-episode psychosis (FEP). The reasons for using cannabis and the effect of cannabis on clinical features have not received enough attention either. We aim therefore, to investigate sex differences in the reasons for cannabis use and to determine the effects of sex, cannabis use and their interaction on clinical variables at admission and at discharge from the inpatient unit. 204 first-admitted FEPs in two inpatient units in Spain were included. The reasons for using cannabis were determined using the Dixon questionnaire. Clinical variables were compared between sexes and between cannabis users and non-users. Cannabis use was more frequent in males, but females were more likely to smoke cannabis to "feel relaxed". There was a main effect of sex on positive psychotic symptoms and antipsychotics dose and an interaction effect of cannabis and sex on global functioning at discharge .Our findings show sex differences in the reasons for cannabis use and in some clinical and treatment characteristics among FEP patients. More studies focusing on gender perspectives are needed to develop more individualized treatments.
目前，研究性别对首发精神分裂症（FEP）患者的临床和治疗特征影响的研究较少。对于导致使用大麻的原因以及大麻对临床特征的影响，也没有得到足够的关注。因此，本研究旨在调查使用大麻的原因是否存在性别差异，并确定性别、大麻使用及其相互作用对住院患者入院和出院时临床变量的影响。该研究纳入了西班牙两个住院病房的 204 例首发 FEP 患者。使用 Dixon 问卷确定使用大麻的原因。比较了不同性别之间以及大麻使用者和非使用者之间的临床变量。男性使用大麻的频率更高，但女性更倾向于通过吸食大麻来“放松”。性别对阳性精神病症状和抗精神病药物剂量有主要影响，大麻和性别的相互作用对出院时的总体功能有影响。本研究结果表明，FEP 患者使用大麻的原因以及某些临床和治疗特征存在性别差异。需要更多关注性别视角的研究来制定更个体化的治疗方案。
