School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu, China.
Crit Rev Food Sci Nutr. 2021;61(6):1049-1064. doi: 10.1080/10408398.2020.1753165. Epub 2020 Apr 15.
vitexin, an apigenin-8-C-glucoside, is widely present in numerous edible and medicinal plants. vitexin possesses a variety of bioactive properties, including antioxidation, anti-inflammation, anti-cancer, neuron-protection, and cardio-protection. Other beneficial health effects, such as fat reduction, glucose metabolism, and hepatoprotection, have also been reported in recent studies. This review briefly discusses the absorption and metabolism of vitexin, as well as its influence on gut microbiota. Recent advances in understanding the pharmacological and biological effects of vitexin are then reviewed. Improved knowledge of the absorption, metabolism, bioactivity, and molecular targets of vitexin is crucial for the better utilization of this emerging nutraceutical as a chemopreventive and chemotherapeutic agent.
牡荆素，一种芹菜素-8-C-葡萄糖苷，广泛存在于许多食用和药用植物中。牡荆素具有多种生物活性，包括抗氧化、抗炎、抗癌、神经元保护和心脏保护。最近的研究还报道了其他有益的健康影响，如减肥、葡萄糖代谢和保肝。本文简要讨论了牡荆素的吸收和代谢，以及它对肠道微生物群的影响。然后综述了近年来对牡荆素药理和生物学作用的认识进展。更好地了解牡荆素的吸收、代谢、生物活性和分子靶点，对于更好地利用这种新兴的营养保健品作为化学预防和化学治疗剂至关重要。
