Gao Hua, Gao Qing, Sun Jinlan
Department of Oral Medicine, Central Hospital of Yingkou, Yingkou, China.
Disease Control and Prevention Center, Shenyang, China.
Front Pediatr. 2020 Mar 27;8:96. doi: 10.3389/fped.2020.00096. eCollection 2020.
Our goal was to analyze the value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in the prognosis of pediatrics with parotid mucoepidermoid carcinoma (MEC). Patients (≤ 18 years old) undergoing surgical treatment for primary parotid MEC were enrolled from multiple clinical centers retrospectively. The χ-test was used to analyze the associations between clinicopathological variables and the NLR. The main study endpoints were recurrence-free survival (RFS) and disease-specific survival (DSS). The prognostic value of NLR was assessed by Kaplan-Meier method and Cox model analysis. There were 88 patients included in total, with mean NLR of 2.32 (range, 1.8-6.0). Histologic tumor grade and tumor stage were associated with the NLR significantly. The 10-year RFS rates were 98 and 81% for patients with an NLR < 2.32 and patients with an NLR ≥ 2.32, respectively, the difference was significant ( = 0.010). The 10-year DSS rate was 97 and 81% for patients with an NLR < 2.32 and patients with an NLR ≥ 2.32, respectively; the difference was not significant ( = 0.072). The independence of NLR in predicting the RFS was further confirmed in Cox model analysis. The NLR significantly affects the prognosis in pediatrics with primary parotid MEC.
我们的目标是分析术前中性粒细胞与淋巴细胞比值（NLR）在小儿腮腺黏液表皮样癌（MEC）预后中的价值。回顾性纳入多个临床中心接受原发性腮腺MEC手术治疗的患者（≤18岁）。采用χ检验分析临床病理变量与NLR之间的关联。主要研究终点为无复发生存期（RFS）和疾病特异性生存期（DSS）。通过Kaplan-Meier法和Cox模型分析评估NLR的预后价值。共纳入88例患者，平均NLR为2.32（范围1.8 - 6.0）。组织学肿瘤分级和肿瘤分期与NLR显著相关。NLR < 2.32和NLR≥2.32的患者10年RFS率分别为98%和81%，差异有统计学意义（=0.010）。NLR < 2.32和NLR≥2.32的患者10年DSS率分别为97%和81%；差异无统计学意义（=0.072）。Cox模型分析进一步证实了NLR在预测RFS方面的独立性。NLR显著影响原发性腮腺MEC患儿的预后。
