Xu Chunmiao, Yuan Junhui, Du Wei, Wu Junfu, Fang Qigen, Zhang Xu, Li Hailiang
Department of Radiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Front Oncol. 2020 Jan 29;10:39. doi: 10.3389/fonc.2020.00039. eCollection 2020.
The neutrophil-to-lymphocyte ratio (NLR) has been reported to be associated with survival in solid malignancies. The main goal was to evaluate the prognostic significance of the NLR in patients with p16-negative squamous cell carcinoma of unknown primary (SCCUP) in head and neck. The association between the NLR and clinical pathologic variables was evaluated by the chi-square test. The primary endpoint of interest was disease-specific survival (DSS). Univariate and Coxmodel analyses were used to evaluate prognostic factors. A total of 153 patients were included in the analysis. Cancer cachexia was noted in 10 patients. The mean NLR value was 3.9 (range: 1.4-8.3). A high NLR was significantly associated with cancer cachexia development. The 5-year DSS rate was 58%. In patients with NLRs varying from 1.4 to 3.7, the 5-year DSS rate was 71%; in patients with NLRs varying from 3.7 to 6.0, the 5-year DSS rate was 57%; in patients with NLRs varying from 6.0 to 8.3, the 5-year DSS rate was 39%, and the difference was significant ( = 0.001). Further Cox model analysis confirmed the independence of the NLR in predicting survival. In patients with p16-negative SCCUP, an NLR ≥ 6.0 is significantly associated with worse prognosis.
据报道，中性粒细胞与淋巴细胞比值（NLR）与实体恶性肿瘤的生存率相关。主要目的是评估NLR在头颈部p16阴性原发灶不明的鳞状细胞癌（SCCUP）患者中的预后意义。通过卡方检验评估NLR与临床病理变量之间的关联。感兴趣的主要终点是疾病特异性生存率（DSS）。采用单因素分析和Cox模型分析来评估预后因素。共有153例患者纳入分析。10例患者出现癌症恶病质。NLR的平均值为3.9（范围：1.4 - 8.3）。高NLR与癌症恶病质的发生显著相关。5年DSS率为58%。NLR在1.4至3.7之间的患者，5年DSS率为71%；NLR在3.7至6.0之间的患者，5年DSS率为57%；NLR在6.0至8.3之间的患者，5年DSS率为39%，差异有统计学意义（P = 0.001）。进一步的Cox模型分析证实了NLR在预测生存方面的独立性。在p16阴性SCCUP患者中，NLR≥6.0与较差的预后显著相关。
