Departments of Neurosurgery, Borsod County Teaching Hospital, Miskolc, Hungary.
Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Arthritis Res Ther. 2020 Apr 15;22(1):78. doi: 10.1186/s13075-020-02180-5.
For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for performing daily activities. These diseases may be associated with cognitive dysfunction (CD). In RA, CD has been associated with age, lower education and disease duration and activity. Great advances have been achieved in neuropsychiatric SLE in the identification of pathogenic pathways, assessment and possible treatment strategies. SSc rarely exerts direct effects on the brain and cognitive function. However, the psychological burden that includes depression, anxiety and social impact may be high. AIRD patients with sustained disease activity, organ damage or lower education should be evaluated for CD. The control of systemic inflammation together with tailored behavioural cognitive therapies may benefit these patients.
对于患有慢性自身免疫性风湿性疾病（AIRD）的人，如类风湿关节炎（RA）、系统性红斑狼疮（SLE）或系统性硬化症（SSc），正常的认知功能对于日常活动至关重要。这些疾病可能与认知功能障碍（CD）有关。在 RA 中，CD 与年龄、较低的教育程度和疾病持续时间和活动度有关。在神经精神病学 SLE 中，在确定发病途径、评估和可能的治疗策略方面取得了重大进展。SSc 很少对大脑和认知功能产生直接影响。然而，包括抑郁、焦虑和社会影响在内的心理负担可能很高。应评估持续性疾病活动、器官损伤或教育程度较低的 AIRD 患者的 CD。控制全身炎症以及量身定制的行为认知疗法可能使这些患者受益。
