Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University, 11th Carol I Avenue, 700506 Iasi, Romania.
Department of Research, Faculty of Biology, Alexandru Ioan Cuza University, 11th Carol I Avenue, 700506 Iasi, Romania.
Oxid Med Cell Longev. 2019 Aug 14;2019:3492767. doi: 10.1155/2019/3492767. eCollection 2019.
L. (Vatke) is a medicinal plant from the family used in west-African traditional medicine, known for its flavonoid and saponin richness and for its strong antioxidant potential. In the present study, we assessed the effects of polyphenolic extract in the psychological stress-induced rat model of irritable bowel syndrome (IBS), a chronic functional digestive tract disorder marked by immune and inflammatory-related disturbances of central nervous and peripheral intestinal systems, which is often associated with mood disorders including depression and anxiety. Consequently, memory impairment, anxiety and depression behavioral indicators, and cerebral oxidative stress biomarker dynamics were evaluated in a multifactorial heterotypic stress-exposed IBS rats after 6-day gavage with polyphenolic extract (100 mg/kg body weight). Y-maze, elevated plus maze, and forced swimming tests were used for assessing behavioral responses. Administration of the extract exhibited significant anxiolytic and antidepressant-like effects coupled with significantly increased temporal lobe antioxidant enzyme specific activity (superoxide dismutase and glutathione peroxidase) and decreased malondialdehyde levels, a well-known lipid peroxidation marker. Furthermore, linear regression statistical analyses showed significant correlations between the oxidative stress parameters and behavioral tests. In conclusion, our results suggest that the administration of polyphenolic extract could ameliorate mood and cognitive disturbances related to stress-induced in an IBS rat model. This could be also related to cerebral oxidative stress status attenuation.
（Vatke）L. 是一种来自 科的药用植物，在西非传统医学中被广泛使用，因其富含类黄酮和皂苷，以及具有强大的抗氧化潜力而闻名。在本研究中，我们评估了多酚提取物对心理应激诱导的肠易激综合征（IBS）大鼠模型的影响，IBS 是一种慢性功能性消化道疾病，其特征是中枢神经系统和外周肠道系统的免疫和炎症相关紊乱，常与情绪障碍相关，包括抑郁和焦虑。因此，在多酚提取物（100mg/kg 体重）灌胃 6 天后，评估了多因素异质应激暴露的 IBS 大鼠的记忆损伤、焦虑和抑郁行为指标以及大脑氧化应激生物标志物动态。Y 迷宫、高架十字迷宫和强迫游泳试验用于评估行为反应。提取物的给药表现出明显的抗焦虑和抗抑郁样作用，同时颞叶抗氧化酶特定活性（超氧化物歧化酶和谷胱甘肽过氧化物酶）显著增加，丙二醛水平降低，丙二醛是一种众所周知的脂质过氧化标志物。此外，线性回归统计分析显示，氧化应激参数与行为测试之间存在显著相关性。总之，我们的结果表明，多酚提取物的给药可以改善与应激诱导的 IBS 大鼠模型相关的情绪和认知障碍。这可能与大脑氧化应激状态的减弱有关。
