Chadha S, Schaberg A
Department of Pathology, Erasmus University Rotterdam, The Netherlands.
Eur J Obstet Gynecol Reprod Biol. 1988 Dec;29(4):329-38. doi: 10.1016/0028-2243(88)90074-3.
Twenty-four cases with a malignant change involving one of the elements of a benign ovarian dermoid cyst are reported. Squamous cell carcinoma was most frequent. Eighteen patients (75%) were over 50 years of age. The prognosis is rather good if the tumor has not extended beyond the capsule, 85% surviving without detectable disease after 4 months to 9 years. The prognosis is very poor if the tumor has extended beyond the capsule, over 80% dying within 2 years. Hysterectomy with bilateral salpingo-oophorectomy is the treatment of choice, certainly in older patients. Additional treatment with cytostatics or radiation seems to have little influence on the prognosis.
报告了24例良性卵巢皮样囊肿的其中一个成分发生恶变的病例。鳞状细胞癌最为常见。18例患者（75%）年龄超过50岁。如果肿瘤未超出包膜，预后相当好，85%的患者在4个月至9年后存活且无疾病复发迹象。如果肿瘤超出包膜，预后则非常差，超过80%的患者在2年内死亡。子宫切除术加双侧输卵管卵巢切除术是首选治疗方法，对于老年患者尤其如此。辅助使用细胞抑制剂或放疗似乎对预后影响不大。
