三疣梭子蟹肌球蛋白水解物对自发性高血压大鼠的降压作用。
Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats.
机构信息
Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, Fujian 350002, China and College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China.
出版信息
Food Funct. 2020 Apr 30;11(4):3645-3656. doi: 10.1039/c9fo02687h.
In this study, the blood pressure-lowering effects of Trichiurus lepturus myosin hydrolysate (TMH) and its possible mechanism were investigated in spontaneously hypertensive rats (SHRs). After gavage administration of TMH for 4 h, systolic blood pressure (SBP) was significantly decreased in SHRs. Furthermore, the SBP of SHRs remained low at 1 month after daily TMH treatment at 400 mg kg-1. Meanwhile, plasma levels of angiotensin II, bradykinin and nitric oxide in SHRs were ameliorated by TMH. Western blotting also suggested that TMH down-regulated the expression of ICAM-1 and VCAM-1, indicating a strong anti-inflammatory effect. Additionally, nitrotyrosine and collagen I were down-regulated, revealing a significant anti-oxidant effect of TMH. No obvious side effects or toxicity were observed in normal Wistar rats given TMH. Various pathogenic factors related to hypertension were improved by TMH, which may explain the underlying mechanism by which TMH synergistically reduces blood pressure.
本研究探讨了金线鱼肌球蛋白水解物（TMH）的降压作用及其可能的机制。灌胃给予 TMH4 小时后，自发性高血压大鼠（SHR）的收缩压（SBP）显著降低。此外，每日给予 400mg/kg TMH 治疗 1 个月后，SHR 的 SBP 仍保持较低水平。同时，TMH 改善了 SHR 血浆中血管紧张素 II、缓激肽和一氧化氮的水平。Western blot 也表明，TMH 下调了 ICAM-1 和 VCAM-1 的表达，表明其具有很强的抗炎作用。此外，硝基酪氨酸和胶原 I 下调，表明 TMH 具有显著的抗氧化作用。给予 TMH 的正常 Wistar 大鼠未观察到明显的副作用或毒性。TMH 改善了与高血压相关的各种致病因素，这可能解释了 TMH 协同降低血压的潜在机制。
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