MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Public Health Scotland, NHS National Services Scotland, Glasgow, United Kingdom.
J Infect Dis. 2020 Jun 16;222(1):17-25. doi: 10.1093/infdis/jiaa185.
Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. Statistical associations with patient age and sex differed between CoV-229E, CoV-OC43, and CoV-NL63. Furthermore, the timing and magnitude of sCoV outbreaks did not occur concurrently, and coinfections were not reported. With respect to other cocirculating respiratory viruses, we found evidence of positive, rather than negative, interactions with sCoVs. These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. Further work is needed to establish the occurrence/degree of cross-protective immunity conferred across sCoVs and with COVID-19, as well as the role of viral coinfection in COVID-19 disease severity.
在缺乏特定环境流行病学数据的情况下，针对冠状病毒（CoV）病 2019（COVID-19）的公共卫生防范极具挑战性。在此，我们描述了苏格兰西部季节性 CoV（sCoV）和其他共流行病毒的流行病学情况。我们分析了 2005 年至 2017 年间，7 万多例呼吸道疾病患者的分子检测呼吸道病毒的常规诊断数据。CoV-229E、CoV-OC43 和 CoV-NL63 与患者年龄和性别之间的统计关联不同。此外，sCoV 暴发的时间和规模不会同时发生，也没有报告合并感染。关于其他共流行的呼吸道病毒，我们发现了与 sCoV 存在正相互作用（而非负相互作用）的证据。这些发现强调了在 COVID-19 鉴别诊断中考虑共流行病毒的重要性。需要进一步的研究来确定 sCoV 和 COVID-19 之间交叉保护免疫的发生/程度，以及病毒合并感染在 COVID-19 疾病严重程度中的作用。
