School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Department of Pediatrics, Maternity and Child Health Care of Zaozhuang, Zaozhuang, China.
J Drug Target. 2020 Nov;28(9):873-881. doi: 10.1080/1061186X.2020.1757102. Epub 2020 Apr 24.
Core-shell nanoparticles have grown in popularity in the past few years due to their versatile features and multiple biomedical applications as drug delivery systems. In order to improve bioavailability and reduce adverse effects, the biomimetic concept has been integrated into core-shell architectural designs. In this regard, the 'camouflage' shell comprised of various cellular membranes renders these nanoparticles a multifunctional platform that combines the merits of native cellular membranes with the advantages of biomaterials. Since leukocytes have a specific tropism for inflammatory or tumour sites and can infiltrate into these lesions, the marriage of leukocyte cell membrane shell with functional nanoparticle core is expected to achieve long time circulation, targeted delivery and improved ability of overcoming certain physiological barriers. In this review, we focus mainly on the recent development of nanoparticles cloaked with the leukocyte membrane and their applications in different biomedical fields of interest, including cancer therapy, inflammatory regulation and immune modulation. Additionally, current challenges and future prospects of leukocyte membrane coated core-shell nanoparticles are also briefly discussed.
近年来，核壳纳米粒子因其多功能特性和作为药物传递系统的多种生物医学应用而受到广泛关注。为了提高生物利用度和降低不良反应，仿生学的概念已经被整合到核壳结构设计中。在这方面，由各种细胞膜组成的“伪装”壳使这些纳米粒子成为一种多功能平台，将天然细胞膜的优点与生物材料的优点结合在一起。由于白细胞对炎症或肿瘤部位具有特定的趋向性，并能浸润到这些病变部位，因此白细胞细胞膜与功能性纳米粒子核的结合有望实现长时间循环、靶向递送和提高克服某些生理屏障的能力。在这篇综述中，我们主要关注被白细胞膜包裹的纳米粒子的最新进展及其在癌症治疗、炎症调节和免疫调节等不同生物医学领域的应用。此外，还简要讨论了白细胞膜包覆的核壳纳米粒子目前面临的挑战和未来前景。
