Mohale Samyak, Kunde Shalvi Sinai, Wairkar Sarika
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Colloids Surf B Biointerfaces. 2022 Nov;219:112803. doi: 10.1016/j.colsurfb.2022.112803. Epub 2022 Aug 24.
Cell membrane cloaking is an important biomimetic approach for improving drug residence time in the body due to its distinctive concealment ability, making it highly biocompatible and efficient for targeted drug delivery. Leukocytes are considered a fundamental part of the immune system. Leukocyte membrane cloaked nanoparticles offer site-specificity and can escape the opsonization process besides enhanced systemic circulation time. This review emphasizes the anatomical and physiological features of different leukocytes in addition to the preparation and characterization of leukocyte membrane cloaked nanoparticles. It also covers the recent advancements of this biointerfacing platform in cancer therapy, inflammatory disorders, multifunctional targeted therapy and hybrid membrane-coated nanoparticles. However, leukocytes are complex, nucleated cell structures and isolating their membranes poses a greater difficulty. Leukocyte membrane cloaking is an upcoming strategy in the infancy stage; nevertheless, there is immense scope to explore this biomimetic delivery system in terms of clinical transition, particularly for inflammatory diseases and cancer.
细胞膜包覆是一种重要的仿生方法，因其独特的隐蔽能力可提高药物在体内的停留时间，使其具有高度生物相容性且在靶向药物递送方面高效。白细胞被认为是免疫系统的基本组成部分。白细胞膜包覆的纳米颗粒具有位点特异性，除了能延长全身循环时间外，还能逃避调理作用过程。本综述除了强调白细胞膜包覆纳米颗粒的制备和表征外，还着重介绍了不同白细胞的解剖学和生理学特征。它还涵盖了这个生物界面平台在癌症治疗、炎症性疾病、多功能靶向治疗和混合膜包覆纳米颗粒方面的最新进展。然而，白细胞是复杂的有核细胞结构，分离其膜带来更大困难。白细胞膜包覆是一个尚处于起步阶段的新兴策略；尽管如此，在临床转化方面，尤其是针对炎症性疾病和癌症，探索这种仿生递送系统仍有很大空间。
