Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Department of Obstetrics and Gynecology, Saitama Municipal Hospital, Saitama, Japan.
BJOG. 2021 Jan;128(2):329-335. doi: 10.1111/1471-0528.16265. Epub 2020 May 3.
Fetal fractional limb volume has been proposed as a useful measure for quantifying fetal soft tissue development. The aim of this study was to investigate the growth of fractional arm volume (AVol) and fractional thigh volume (TVol) of fetuses with maternal gestational diabetes (GDM) compared with those of fetuses with normal glucose tolerance (NGT). We hypothesised fetal fractional limb volume would be larger in the GDM group than in the NGT group in late gestation.
Exploratory observational study.
Saitama Municipal Hospital.
A total of 165 (125 NGT and 40 GDM) singleton Japanese pregnant women.
AVol and TVol were assessed between 20 and 37 weeks' gestation as cylindrical limb volumes based on 50% of the fetal humeral or femoral diaphysis length. Women were diagnosed as GDM based on the criteria of the Japan Society of Obstetrics and Gynecology.
AVol and TVol were compared between women with NGT and those with GDM at each gestational age period (2-week intervals from 20 to 37 weeks' gestation).
Overall, 287 ultrasound scans were performed (NGT group, 205 scans; GDM group, 82 scans). There was no significant difference of AVol between the groups before 32 weeks' gestation. AVol was significantly larger in the GDM group than in the NGT group after 32 weeks' gestation (P < 0.05). TVol was not statistically different between the groups across gestation.
Detection of variations in fetal AVol may provide greater insight into understanding the origins of altered fetal body proportion in GDM.
AVol, but not TVol, is significantly larger in fetuses with GDM than in those with NGT after 32 weeks' gestation.
胎儿肢体分数体积已被提出作为一种有用的方法来量化胎儿软组织发育。本研究旨在研究患有妊娠期糖尿病（GDM）的胎儿与血糖正常的胎儿（NGT）相比，其胎儿肢体分数体积（AVol）和胎儿肢体分数体积（TVol）的生长情况。我们假设在妊娠晚期，GDM 组的胎儿分数肢体体积大于 NGT 组。
探索性观察性研究。
埼玉市立医院。
共 165 名（125 名 NGT 和 40 名 GDM）单胎日本孕妇。
在 20 至 37 周妊娠期间，根据肱骨或股骨骨干的 50%评估 AVol 和 TVol，作为圆柱状肢体体积。根据日本妇产科协会的标准，将 GDM 诊断为妇女。
在每个妊娠期间（20 周至 37 周妊娠，每 2 周一次），将 NGT 妇女和 GDM 妇女的 AVol 和 TVol 进行比较。
总体而言，共进行了 287 次超声扫描（NGT 组 205 次扫描；GDM 组 82 次扫描）。在 32 周妊娠前，两组之间的 AVol 无显著差异。在 32 周妊娠后，GDM 组的 AVol 明显大于 NGT 组（P < 0.05）。在整个妊娠期间，两组之间的 TVol 无统计学差异。
检测胎儿 AVol 的变化可能会更好地了解 GDM 中胎儿身体比例改变的起源。
在 32 周妊娠后，与 NGT 胎儿相比，GDM 胎儿的 AVol 显著增大，但 TVol 无统计学差异。
