Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
J Obstet Gynaecol Res. 2024 Dec;50(12):2178-2182. doi: 10.1111/jog.16114. Epub 2024 Oct 9.
Birth weight is an important predictor of perinatal complications and long-term health outcomes of offspring. Fetal programming influenced by maternal obesity, overnutrition, and hyperglycemia has been proposed as the fuel overload hypothesis. Recent investigations related with fetal body composition have revealed that neonatal adiposity can be predicted by fetal fat mass, and that maternal insulin resistance and serum leptin level are indicators of fetal adiposity. Based on the current evidence, the origins of obesity can partly be traced back into the fetal life. Further clarification of the determinants of fetal fat mass may lead to the clinical interventions and treatment strategies for fetal growth and development. This effort potentially leads to the elucidation of pathological conditions related with long-term health outcomes and the primary prevention of childhood obesity and early onset metabolic syndrome.
出生体重是围产期并发症和后代长期健康结果的重要预测指标。由母体肥胖、营养过剩和高血糖引起的胎儿编程被提出作为燃料过载假说。最近与胎儿身体成分相关的研究表明，新生儿肥胖可以通过胎儿脂肪量来预测，而母体胰岛素抵抗和血清瘦素水平是胎儿肥胖的指标。基于目前的证据，肥胖的起源部分可以追溯到胎儿期。进一步阐明胎儿脂肪量的决定因素可能会导致针对胎儿生长和发育的临床干预和治疗策略。这一努力可能会阐明与长期健康结果相关的病理状况，并预防儿童肥胖和早期代谢综合征的发生。
