Ikenoue Satoru, Akiba Yohei, Endo Toyohide, Kasuga Yoshifumi, Yakubo Kazumi, Ishii Ryota, Tanaka Mamoru, Ochiai Daigo
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Department of Obstetrics and Gynecology, Saitama Municipal Hospital, Saitama 336-8522, Japan.
J Clin Med. 2021 Jan 29;10(3):485. doi: 10.3390/jcm10030485.
Fetal fractional limb volume is a useful measure for predicting birth weight and newborn adiposity; however, a normal growth curve has been reported solely in the United States. As the birth weight of neonates in Japan is significantly lower than that in the US, fetal fractional limb volume is likely to be smaller in the Japanese population. This study aimed to define the normal growth curve of fractional arm volume (AVol) and thigh volume (TVol) in the Japanese population. Ultrasound scans of 453 AVol and TVol pairs were obtained; each AVol and TVol percentile at each gestational age was calculated. The measured AVol and TVol at each gestational week were also converted to z-scores based on a previous report. The growth curves increased linearly until the second trimester and exponentially in the third trimester. Linear regression showed a significant negative correlation between gestational age and AVol and TVol z-scores. The growth pattern of fetal fractional limb volume in the Japanese population is consistent with, but smaller than, that reported in the US; this difference becomes greater as the gestational age progresses.
胎儿肢体分数体积是预测出生体重和新生儿肥胖程度的一项有用指标；然而，仅在美国报道过正常生长曲线。由于日本新生儿的出生体重显著低于美国，日本人群的胎儿肢体分数体积可能更小。本研究旨在确定日本人群中上肢分数体积（AVol）和大腿体积（TVol）的正常生长曲线。获取了453对AVol和TVol的超声扫描图像；计算了每个孕周的AVol和TVol百分位数。根据先前的报告，每个孕周测量的AVol和TVol也被转换为z分数。生长曲线在孕中期之前呈线性增加，在孕晚期呈指数增加。线性回归显示孕周与AVol和TVol的z分数之间存在显著负相关。日本人群胎儿肢体分数体积的生长模式与美国报道的一致，但数值更小；随着孕周增加，这种差异变得更大。
