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脂质体结合环孢素:玻璃体内注射后的视网膜毒性。

Liposome-bound cyclosporine: retinal toxicity after intravitreal injection.

作者信息

Alghadyan A A, Peyman G A, Khoobehi B, Liu K R

机构信息

LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.

出版信息

Int Ophthalmol. 1988;12(2):105-7. doi: 10.1007/BF00137134.

DOI:10.1007/BF00137134
PMID:3229898
Abstract

The retinal toxicity of intraocular liposome-bound cyclosporine was studied in albino rabbits by means of electrophysiology and histopathology. During a followup period of one month, no histopathological or electroretinographic changes were noted using concentrations of 100, 200 and 500 micrograms injected intravitreally.

摘要

通过电生理学和组织病理学方法,在白化兔中研究了眼内脂质体结合环孢素的视网膜毒性。在为期一个月的随访期内,玻璃体内注射100、200和500微克浓度的药物时,未观察到组织病理学或视网膜电图变化。

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本文引用的文献

1
Rabbit corneal allograft survival following topical administration of cyclosporin A.局部应用环孢素A后兔角膜同种异体移植的存活情况
Invest Ophthalmol Vis Sci. 1982 May;22(5):686-90.
2
A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits.环孢素A预防兔角膜移植排斥反应的安慰剂对照盲法试验。
Br J Ophthalmol. 1982 May;66(5):303-8. doi: 10.1136/bjo.66.5.303.
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Cyclosporin A applied topically to the recipient eye inhibits corneal graft rejection.局部应用于受体眼的环孢素A可抑制角膜移植排斥反应。
眼部药物、基因和细胞递送系统以及高级治疗药品。
Turk J Ophthalmol. 2018 Jun;48(3):132-141. doi: 10.4274/tjo.32458. Epub 2018 Jun 28.
4
In vivo release and retinal toxicity of cyclosporine-loaded intravitreal device.载环孢素玻璃体内植入装置的体内释放及视网膜毒性
Doc Ophthalmol. 2015 Dec;131(3):207-14. doi: 10.1007/s10633-015-9520-z. Epub 2015 Nov 17.
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Nanocarriers of nanotechnology in retinal diseases.纳米技术的纳米载体在视网膜疾病中的应用
Saudi J Ophthalmol. 2014 Oct;28(4):304-9. doi: 10.1016/j.sjopt.2014.02.009. Epub 2014 Mar 5.
6
Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: comparative study with the conventional cyclosporin A emulsion.载环孢素 A 的超临界流体介导脂质体治疗兔干燥性眼综合征:与常规环孢素 A 乳剂的对比研究。
Int J Nanomedicine. 2014 Aug 8;9:3791-800. doi: 10.2147/IJN.S65601. eCollection 2014.
7
Diabetic retinopathy - An update.糖尿病视网膜病变——最新进展
Saudi J Ophthalmol. 2011 Apr;25(2):99-111. doi: 10.1016/j.sjopt.2011.01.009. Epub 2011 Jan 31.
8
Liposomes and nanotechnology in drug development: focus on ocular targets.脂质体和纳米技术在药物开发中的应用:关注眼部靶标。
Int J Nanomedicine. 2013;8:495-503. doi: 10.2147/IJN.S30725. Epub 2013 Feb 14.
9
Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes.兔眼玻璃体内注射脂质体包裹型和游离型氧氟沙星后的视网膜毒性
Int Ophthalmol. 1998;22(3):133-43. doi: 10.1023/a:1006137100444.
10
Corticosteroids and daunomycin in the prevention of experimental proliferative vitreoretinopathy induced by macrophages.皮质类固醇和柔红霉素预防巨噬细胞诱导的实验性增殖性玻璃体视网膜病变
Graefes Arch Clin Exp Ophthalmol. 1993 Feb;231(2):109-14. doi: 10.1007/BF00920223.
Clin Exp Immunol. 1981 Jul;45(1):173-7.
4
Effect of cyclosporin A on the survival of corneal grafts in rabbits.环孢素A对兔角膜移植片存活的影响。
Br J Ophthalmol. 1980 Mar;64(3):148-53. doi: 10.1136/bjo.64.3.148.
5
Temperature-dependent permeability of large unilamellar liposomes.大单层脂质体的温度依赖性通透性
Chem Phys Lipids. 1984 Mar;34(3):245-56. doi: 10.1016/0009-3084(84)90059-8.
6
Suppression of corneal allograft rejection by cyclosporin A.环孢素A对角膜移植排斥反应的抑制作用。
Arch Ophthalmol. 1981 Sep;99(9):1640-3. doi: 10.1001/archopht.1981.03930020514024.
7
Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits.玻璃体内注射脂质体两性霉素B对兔的毒性降低。
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8
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