Fetz Allison E, Radic Marko Z, Bowlin Gary L
Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA.
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Tissue Eng Part B Rev. 2021 Apr;27(2):95-106. doi: 10.1089/ten.TEB.2020.0028. Epub 2020 May 26.
Biomaterial-guided tissue regeneration uses biomaterials to stimulate and guide the body's endogenous, regenerative processes to drive functional tissue repair and regeneration. To be successful, cell migration into the biomaterials is essential, which requires angiogenesis to maintain cell viability. Neutrophils, the first cells responding to an implanted biomaterial, are now known to play an integral part in angiogenesis in multiple tissues and exhibit considerable potential for driving angiogenesis in the context of tissue regeneration. In terms of biomaterial-guided tissue regeneration, harnessing the proangiogenic potential of the neutrophil through its robust secretion of matrix metalloproteinase 9 (MMP-9) may provide a mechanism to improve biomaterial performance by initiating matrix reprogramming. This review will discuss neutrophils as matrix reprogrammers and what is currently known about their ability to create a microenvironment that is more conducive for angiogenesis and tissue regeneration through the secretion of MMP-9. It will first review a set of ground-breaking studies in tumor biology and then present an overview of what is currently known about neutrophils and MMP-9 in biomaterial vascularization. Finally, it will conclude with potential strategies and considerations to engage neutrophils in biomaterial-guided angiogenesis and tissue regeneration. Impact statement This review draws attention to a highly neglected topic in tissue engineering, the role of neutrophils in biomaterial-guided tissue regeneration and angiogenesis. Moreover, it highlights their abundant secretion of matrix metalloproteinase 9 (MMP-9) for matrix reprogramming, a topic with great potential yet to be vetted in the literature. It presents strategies and considerations for designing the next generation of immunomodulatory biomaterials. While there is literature discussing the overall role of neutrophils in angiogenesis, there are a limited number of review articles focused on this highly relevant topic in the context of biomaterial integration and tissue regeneration, making this a necessary and impactful article.
生物材料引导的组织再生利用生物材料来刺激和引导机体的内源性再生过程，以驱动功能性组织修复和再生。要取得成功，细胞迁移到生物材料中至关重要，这需要血管生成来维持细胞活力。中性粒细胞是对植入生物材料做出反应的首批细胞，现在已知它们在多种组织的血管生成中发挥着不可或缺的作用，并且在组织再生的背景下具有驱动血管生成的巨大潜力。就生物材料引导的组织再生而言，通过中性粒细胞大量分泌基质金属蛋白酶9（MMP-9）来利用其促血管生成潜力，可能提供一种通过启动基质重编程来改善生物材料性能的机制。本综述将讨论中性粒细胞作为基质重编程者，以及目前已知它们通过分泌MMP-9创造更有利于血管生成和组织再生的微环境的能力。它将首先回顾肿瘤生物学中的一系列开创性研究，然后概述目前对生物材料血管化中中性粒细胞和MMP-9的了解。最后，将总结使中性粒细胞参与生物材料引导的血管生成和组织再生的潜在策略和注意事项。影响声明 本综述提请人们关注组织工程中一个高度被忽视的主题，即中性粒细胞在生物材料引导的组织再生和血管生成中的作用。此外，它强调了它们大量分泌基质金属蛋白酶9（MMP-9）用于基质重编程，这是一个具有巨大潜力但尚未在文献中得到审查的主题。它提出了设计下一代免疫调节生物材料的策略和注意事项。虽然有文献讨论中性粒细胞在血管生成中的总体作用，但在生物材料整合和组织再生的背景下，专注于这个高度相关主题的确切综述文章数量有限，这使得本文成为一篇必要且有影响力的文章。
