Sousa Ana Beatriz, Barbosa Judite N
i3S-Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal.
INEB-Instituto de Engenharia Biomédica, Rua Alfredo Allen, 208, 4200-125 Porto, Portugal.
J Funct Biomater. 2023 Jun 19;14(6):327. doi: 10.3390/jfb14060327.
Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair and restore function of damaged tissues or organs. This can be achieved in different ways, either by promoting endogenous tissue repair or by using biomaterials or medical devices to replace damaged tissues. The understanding of the interactions of the immune system with biomaterials and how immune cells participate in the process of wound healing are critical for the development of successful solutions. Until recently, it was thought that neutrophils participate only in the initial steps of an acute inflammatory response with the role of eliminating pathogenic agents. However, the appreciation that upon activation the longevity of neutrophils is highly increased and the fact that neutrophils are highly plastic cells and can polarize into different phenotypes led to the discovery of new and important actions of neutrophils. In this review, we focus on the roles of neutrophils in the resolution of the inflammatory response, in biomaterial-tissue integration and in the subsequent tissue repair/regeneration. We also discuss the potential of neutrophils for biomaterial-based immunomodulation.
组织工程与再生医学正在寻求临床有效的解决方案，以修复和恢复受损组织或器官的功能。这可以通过不同的方式实现，要么促进内源性组织修复，要么使用生物材料或医疗设备来替代受损组织。了解免疫系统与生物材料的相互作用以及免疫细胞如何参与伤口愈合过程，对于成功解决方案的开发至关重要。直到最近，人们还认为中性粒细胞仅参与急性炎症反应的初始阶段，其作用是清除病原体。然而，人们认识到，激活后中性粒细胞的寿命会大大延长，而且中性粒细胞是高度可塑性的细胞，能够极化为不同的表型，这导致了对中性粒细胞新的重要作用的发现。在这篇综述中，我们重点关注中性粒细胞在炎症反应消退、生物材料-组织整合以及随后的组织修复/再生中的作用。我们还讨论了中性粒细胞在基于生物材料的免疫调节方面的潜力。
