From the Department of Allied Health Sciences, University of North Carolina, Chapel Hill (J.M.C.).
Department of Cognitive Sciences (A.W., R.S.), University of California, Irvine.
Stroke. 2020 May;51(5):1442-1450. doi: 10.1161/STROKEAHA.120.028932. Epub 2020 Apr 17.
Background and Purpose- Low-frequency oscillations reflect brain injury but also contribute to normal behaviors. We examined hypotheses relating electroencephalography measures, including low-frequency oscillations, to injury and motor recovery poststroke. Methods- Patients with stroke completed structural neuroimaging, a resting-state electroencephalography recording and clinical testing. A subset admitted to an inpatient rehabilitation facility also underwent serial electroencephalography recordings. The relationship that electroencephalography measures (power and coherence with leads overlying ipsilesional primary motor cortex [iM1]) had with injury and motor status was assessed, focusing on delta (1-3 Hz) and high-beta (20-30 Hz) bands. Results- Across all patients (n=62), larger infarct volume was related to higher delta band power in bilateral hemispheres and to higher delta band coherence between iM1 and bilateral regions. In chronic stroke, higher delta power bilaterally correlated with better motor status. In subacute stroke, higher delta coherence between iM1 and bilateral areas correlated with poorer motor status. These coherence findings were confirmed in serial recordings from 18 patients in an inpatient rehabilitation facility. Here, interhemispheric coherence between leads overlying iM1 and contralesional M1 was elevated at inpatient rehabilitation facility admission compared with healthy controls (n=22), declining to control levels over time. Decreases in interhemispheric coherence between iM1 and contralesional M1 correlated with better motor recovery. Conclusions- Delta band coherence with iM1 related to greater injury and poorer motor status subacutely, while delta band power related to greater injury and better motor status chronically. Low-frequency oscillations reflect both injury and recovery after stroke and may be useful biomarkers in stroke recovery and rehabilitation.
背景与目的-低频振荡反映了脑损伤，但也有助于正常行为。我们研究了与脑电图测量相关的假设，包括低频振荡，以了解中风后的损伤和运动恢复情况。方法-中风患者完成了结构神经影像学、静息态脑电图记录和临床测试。一部分入住住院康复设施的患者还接受了系列脑电图记录。评估了脑电图测量（功率和与同侧初级运动皮层[iM1]上方导联的相干性）与损伤和运动状态的关系，重点关注 delta（1-3 Hz）和高-beta（20-30 Hz）频段。结果-在所有患者（n=62）中，更大的梗死体积与双侧半球的 delta 频段功率升高以及 iM1 和双侧区域之间的 delta 频段相干性升高有关。在慢性中风中，双侧 delta 功率升高与更好的运动状态相关。在亚急性中风中，iM1 和双侧区域之间的 delta 相干性升高与更差的运动状态相关。这些相干性发现得到了 18 名住院康复设施患者的系列记录的证实。在这里，与健康对照组（n=22）相比，住院康复设施入院时 iM1 上方导联的半球间相干性升高，随着时间的推移下降至对照水平。iM1 和对侧 M1 之间半球间相干性的降低与运动恢复的改善相关。结论-亚急性时，iM1 与 delta 波段相干性与更大的损伤和更差的运动状态有关，而慢性时，delta 波段功率与更大的损伤和更好的运动状态有关。低频振荡反映了中风后的损伤和恢复，可能是中风恢复和康复的有用生物标志物。
