一种通过纳米粘土掺入增强稳定性的可 3D 打印的 TEMPO 氧化细菌纤维素/海藻酸盐水凝胶。
A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation.
机构信息
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
出版信息
Carbohydr Polym. 2020 Jun 15;238:116207. doi: 10.1016/j.carbpol.2020.116207. Epub 2020 Apr 8.
Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields. Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material. However, its long-term stability of structure has always been a problem. In this work, we showed a green nanocomposite printing ink based on 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls). The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.
三维（3D）打印为医学领域的大规模定制提供了一种制造可重复的个性化结构的新方法。考虑到材料在组成和微观结构上与生物组织的相似性，基于多糖的水凝胶是一种很有前途的打印材料。然而，其结构的长期稳定性一直是一个问题。在这项工作中，我们展示了一种基于 2,2,6,6-四甲基哌啶-1-氧自由基（TEMPO）-氧化细菌纤维素（TOBC）、海藻酸钠（SA）和纳米蒙脱土（Xls）的绿色纳米复合打印墨水。由 3D 打印墨水制备的 TOBC/SA/Xls 水凝胶不仅表现出结构稳定性，而且还表现出蛋白质的长期释放行为，这在药物释放、生物医学装置和组织工程等医学应用中很有吸引力。
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