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内生菌株sp. SS1-1的基因组序列数据草图，该菌株对人肺癌A549细胞系具有细胞毒性。

Draft genome sequence data of sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line.

作者信息

Nguyen Quan Dang, Truong Phung Minh, Vo Thao Nguyen Thanh, Chu Truc Dao Xuan, Nguyen Chuong Hoang

机构信息

Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Center for Research and Application in Bioscience, Ho Chi Minh City, Vietnam.

出版信息

Data Brief. 2020 Apr 8;30:105497. doi: 10.1016/j.dib.2020.105497. eCollection 2020 Jun.

DOI:10.1016/j.dib.2020.105497
PMID:32300629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7153288/
Abstract

We report in this article the cytotoxicity of sp. SS1-1 against the human lung cancer A549 cell line, its draft genome sequence and a total of 20 predicted secondary metabolite biosynthetic gene clusters. sp. SS1-1 was an endophytic bacterial strain isolated from the plant in Ho Chi Minh City, Vietnam. When cultured in the PY medium, this strain shows a cytotoxic effect on the A549 cell line. The draft genome of sp. SS1-1 has four contigs of total 7,815,656 bp and the GC content of this genome is 72.2%. AntiSMASH analysis reveals 20 putative biosynthetic gene clusters for the largest contig. The genome sequencing of sp. SS1-1 is essential for the molecular identification of gene cluster(s) responsible for secondary metabolite(s) with cytotoxic activity.

摘要

我们在本文中报告了sp. SS1-1对人肺癌A549细胞系的细胞毒性、其基因组草图序列以及总共20个预测的次级代谢物生物合成基因簇。sp. SS1-1是从越南胡志明市的植物中分离出的一种内生细菌菌株。在PY培养基中培养时，该菌株对A549细胞系表现出细胞毒性作用。sp. SS1-1的基因组草图有4个重叠群，总长7,815,656 bp，该基因组的GC含量为72.2%。抗SMASH分析揭示了最大重叠群的20个假定生物合成基因簇。sp. SS1-1的基因组测序对于分子鉴定具有细胞毒性活性的次级代谢物的基因簇至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/7153288/fe03515292e8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/7153288/7c7b857b1001/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/7153288/fe03515292e8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/7153288/7c7b857b1001/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/7153288/fe03515292e8/gr2.jpg

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2
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J Fungi (Basel). 2018 May 30;4(2):65. doi: 10.3390/jof4020065.
3
Canu: scalable and accurate long-read assembly via adaptive -mer weighting and repeat separation.Canu：通过自适应k-mer加权和重复序列分离实现可扩展且准确的长读长序列拼接
Genome Res. 2017 May;27(5):722-736. doi: 10.1101/gr.215087.116. Epub 2017 Mar 15.
4
NCBI prokaryotic genome annotation pipeline.美国国立生物技术信息中心原核生物基因组注释管道
Nucleic Acids Res. 2016 Aug 19;44(14):6614-24. doi: 10.1093/nar/gkw569. Epub 2016 Jun 24.
5
An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death.从长春花中分离出的内生真菌罗克塔马拉色霉菌可产生长春新碱和长春碱，二者均可诱导细胞凋亡性死亡。
PLoS One. 2015 Dec 23;10(12):e0144476. doi: 10.1371/journal.pone.0144476. eCollection 2015.
6
BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs.BUSCO：利用单拷贝同源基因评估基因组组装和注释的完整性。
Bioinformatics. 2015 Oct 1;31(19):3210-2. doi: 10.1093/bioinformatics/btv351. Epub 2015 Jun 9.
7
Pilon: an integrated tool for comprehensive microbial variant detection and genome assembly improvement.Pilon：一种用于全面微生物变异检测和基因组组装改进的集成工具。
PLoS One. 2014 Nov 19;9(11):e112963. doi: 10.1371/journal.pone.0112963. eCollection 2014.
8
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