巴拿马查瓜林托拉病毒的基因组特征：多个基因组片段重配的证据。

Genomic characterization of Changuinola viruses from Panama: evidence for multiple genome segment reassortment.

机构信息

Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

出版信息

Virus Genes. 2020 Aug;56(4):527-530. doi: 10.1007/s11262-020-01758-0. Epub 2020 Apr 16.

DOI:10.1007/s11262-020-01758-0

PMID:32300929

Abstract

The complete coding sequences of five divergent strains of Changuinola virus (CGLV), collected over a 16-year period in Panama, were determined, using viral metagenomics. Each strain had 10 RNA segments that encoded structural and non-structural proteins with amino acid identities ranging from 33 to 99% with sequences of other 15 members of the Changuinola virus (Reoviridae: Orbivirus) species group. Genetic analyses of the five Panamanian virus strains revealed probable reassortment among multiple segments of the viruses.

摘要

采用病毒宏基因组学方法，确定了在巴拿马 16 年间收集的五种不同的 Changuinola 病毒（CGLV）分离株的完整编码序列。每个毒株都有 10 个 RNA 片段，编码结构蛋白和非结构蛋白，与 Changuinola 病毒（Reoviridae：Orbivirus）种组的其他 15 个成员的序列的氨基酸同一性为 33%至 99%。对来自巴拿马的五种病毒株的遗传分析显示，病毒的多个片段可能发生了重组。