Department of Diabetes and Endocrinology, Salford Royal Hospital, Stott Lane, Salford, Greater Manchester M6 8HD, UK.
The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.
Prim Care Companion CNS Disord. 2020 Apr 16;22(2):19m02552. doi: 10.4088/PCC.19m02552.
The number of prescriptions for antidepressants (ADs) in England and Wales has almost doubled in the past decade. The objective of this article is to describe the current prescribing rates of different antidepressants by general practice (GP) practice.
We collated the prescribing behavior in each GP practice in the year April 1, 2017, to March 31, 2018. The monthly GP practice prescribing data reports for medication prescribing for each British National Formulary code and practice, as well as the prescriptions, quantity, and costs were examined in relation to prescribing practice.
The data showed that 2.1 billion doses of antidepressant were prescribed to a total population of 52 million people. That equates to 11% of individuals taking ≥ 1 antidepressants on any day. Selective serotonin reuptake inhibitors (SSRIs) were the most prescribed class of ADs, with sertraline the most prescribed SSRI. The other most prescribed ADs were citalopram, fluoxetine, and mirtazapine. Some older agents, such as trimipramine and doxepin, are prescribed at a very high tariff.
Broadly, the findings are in keeping with National Institute for Health and Care Excellence guidance in that the bulk of prescriptions were for SSRIs. Regular audit of patient treatment at a general practice level will ensure appropriate targeted use of licensed medications as supported by the evidence base.
在过去的十年中，英格兰和威尔士的抗抑郁药（AD）处方数量几乎翻了一番。本文的目的是描述按一般实践（GP）实践开出的不同抗抑郁药的当前开方率。
我们整理了 2017 年 4 月 1 日至 2018 年 3 月 31 日期间每个 GP 实践中的处方行为。根据处方实践，审查了每个英国国家处方代码和实践的药物每月 GP 实践处方数据报告，以及处方、数量和费用。
数据显示，共有 21 亿剂抗抑郁药开给了 5200 万总人口，这相当于每天有 11%的人服用≥1 种抗抑郁药。选择性 5-羟色胺再摄取抑制剂（SSRIs）是处方最多的一类 AD，舍曲林是处方最多的 SSRI。其他常用的 AD 有西酞普兰、氟西汀和米氮平。一些较老的药物，如曲米帕明和多塞平，以很高的价格开方。
总体而言，这些发现与国家卫生与保健卓越研究所的指导原则一致，即大部分处方是 SSRIs。在一般实践层面上定期审查患者的治疗情况，将确保根据循证基础，对许可药物进行适当的有针对性使用。
