Drp1 在心脏中的线粒体自噬和细胞死亡中的作用。
The role of Drp1 in mitophagy and cell death in the heart.
机构信息
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, USA.
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, USA.
出版信息
J Mol Cell Cardiol. 2020 May;142:138-145. doi: 10.1016/j.yjmcc.2020.04.015. Epub 2020 Apr 14.
Abstract
Maintenance of mitochondrial function and integrity is critical for normal cell survival, particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well-coordinated quality control mechanisms in cardiomyocytes, involving mitochondrial biogenesis, mitochondrial dynamics-fission and fusion, and mitophagy, act to protect against mitochondrial dysfunction. Mitochondrial fission, which requires dynamin-related protein 1 (Drp1), is essential for segregation of damaged mitochondria for degradation. Alterations in this process have been linked to cardiomyocyte apoptosis and cardiomyopathy. In this review, we discuss the role of Drp1 in mitophagy and apoptosis in the context of cardiac pathology, including myocardial ischemia and heart failure.
摘要
维持线粒体的功能和完整性对于正常细胞的存活至关重要，特别是对于能量需求高的非分裂细胞，如心肌细胞。心肌细胞中线粒体生物发生、线粒体动力学分裂和融合以及线粒体自噬等协调良好的质量控制机制可防止线粒体功能障碍。需要 dynamin-related protein 1 (Drp1) 的线粒体分裂对于受损线粒体的分离和降解至关重要。该过程的改变与心肌细胞凋亡和心肌病有关。在本文中，我们将讨论 Drp1 在心肌缺血和心力衰竭等心脏病理学中的自噬和凋亡中的作用。
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