轻度认知障碍患者睡眠的客观测量：系统评价和荟萃分析。
Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis.
机构信息
School of Psychology, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia; Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia.
Healthy Brain Ageing Program, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia; Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia.
出版信息
Sleep Med Rev. 2020 Aug;52:101308. doi: 10.1016/j.smrv.2020.101308. Epub 2020 Mar 13.
Older adults with mild cognitive impairment (MCI) are at-risk of developing dementia, particularly Alzheimer's disease. While some research suggests that alterations in sleep architecture may mediate cognitive decline, the nature and magnitude of changes to sleep macro- (sleep stages) and micro-architecture (electroencephalography (EEG) oscillations) in MCI is not yet clear. This study aimed to systematically review and meta-analyse case-control studies objectively measuring sleep in MCI. A systematic search was conducted using PubMed, Scopus, Web of Science, Embase and Psycinfo databases and after review, a total of 10 studies met inclusion criteria. Of these, all reported sleep macro-architecture and four reported micro-architecture outcomes. A combined total of 430 participants (209 with and 221 without MCI) underwent objective sleep assessments in the included full text articles. Findings show that compared to healthy controls, those with MCI have pronounced changes in sleep macro-architecture with greater wake after sleep onset, reduced total sleep time, lower sleep efficiency, longer sleep onset latency, longer rapid eye movement sleep (REM) latency, reduced REM sleep, greater N1 sleep, and worse severity of hypoxemia. Pooling of sleep micro-architecture EEG measures was not possible due to limited studies, however reduced spindles in non-REM sleep and greater EEG slowing in REM sleep were reported.
患有轻度认知障碍 (MCI) 的老年人有发展为痴呆症的风险，特别是阿尔茨海默病。虽然一些研究表明睡眠结构的改变可能会介导认知能力下降，但 MCI 中睡眠宏观结构（睡眠阶段）和微观结构（脑电图 (EEG) 波动）的性质和程度尚不清楚。本研究旨在系统地综述和荟萃分析客观测量 MCI 睡眠的病例对照研究。使用 PubMed、Scopus、Web of Science、Embase 和 Psycinfo 数据库进行了系统搜索，经过审查，共有 10 项研究符合纳入标准。其中，所有研究均报告了睡眠宏观结构，4 项研究报告了微结构结果。共有 430 名参与者（209 名患有和 221 名未患有 MCI）在纳入的全文文章中接受了客观的睡眠评估。研究结果表明，与健康对照组相比，MCI 患者的睡眠宏观结构有明显变化，表现为睡眠后觉醒时间增加、总睡眠时间减少、睡眠效率降低、睡眠潜伏期延长、快速眼动睡眠 (REM) 潜伏期延长、REM 睡眠时间减少、N1 睡眠增加以及缺氧严重程度增加。由于研究有限，无法对睡眠微观结构 EEG 测量值进行汇总，但据报道，非快速眼动睡眠中的纺锤波减少和 REM 睡眠中的 EEG 减慢。
Zotero 插件