Division of Pediatrics, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, PR China.
Division of Clinical Pharmacy, The First Affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, Hunan, 410005, PR China.
J Clin Virol. 2020 Jun;127:104353. doi: 10.1016/j.jcv.2020.104353. Epub 2020 Apr 10.
The outbreak of a new coronavirus, first reported in Wuhan, China, is spreading around the world. Information on the characteristics of children with Coronavirus Disease 2019 (COVID-19) is limited.
In this retrospective study, we recruited 10 children infected with SARS-COV-2 from January 27 to March 10, 2020, in Changsha, China. We report the epidemiological, clinical, laboratory, and high-resolution CT findings for these children. Qualitative descriptive analysis was used to describe the key results.
Ten children were included. Three were male and seven were female. Three were from Wuhan, Hubei Province, and seven were from Changsha. All had a history of close contact with adults with COVID-19 before the onset of disease. Clinical manifestations included fever in four cases, respiratory symptoms in three cases, febrile convulsions in one case, vomiting in one case, abdominal pain in one case, and asymptomatic infection in two cases. All the children tested positive for nucleic acid in throat swabs at admission. Stool swabs of three cases were positive for nucleic acid after several days of fever. In nine children, blood routine results were normal, whereas in one case the white blood cell count was elevated. In four cases, CT findings of the lungs showed light ground-glass opacities, one case showed changes similar to bronchopneumonia, and the remaining cases were normal. All were treated with symptomatic support without complications.
Our findings indicate that intrafamily transmission may be the main form of transmission of COVID-19 in children, and persistent intestinal excretion of virus is another characteristic among children. The results of stool swab tests should be considered for discharge and release from isolation.
新型冠状病毒首次在中国武汉报道，目前正在全球范围内传播。关于儿童 2019 冠状病毒病（COVID-19）特征的信息有限。
在这项回顾性研究中，我们招募了 2020 年 1 月 27 日至 3 月 10 日期间在中国长沙感染 SARS-CoV-2 的 10 例儿童。我们报告了这些儿童的流行病学、临床、实验室和高分辨率 CT 结果。采用定性描述性分析来描述关键结果。
共纳入 10 例患儿。男 3 例，女 7 例。3 例来自湖北省武汉市，7 例来自长沙市。所有患儿在发病前均有与 COVID-19 成人密切接触史。临床表现包括发热 4 例，呼吸道症状 3 例，热性惊厥 1 例，呕吐 1 例，腹痛 1 例，无症状感染 2 例。所有患儿入院时咽拭子核酸检测均为阳性。3 例发热数天后粪便拭子核酸检测阳性。9 例患儿血常规结果正常，1 例白细胞计数升高。4 例胸部 CT 表现为肺部磨玻璃样阴影，1 例表现为类似支气管肺炎改变，其余均正常。所有患儿均接受对症支持治疗，无并发症发生。
我们的研究结果表明，家庭内传播可能是儿童 COVID-19 的主要传播形式，病毒持续肠道排出是儿童的另一个特征。对于出院和解除隔离，应考虑粪便拭子检测结果。
