Sturrock Beattie Rh, Chevassut Timothy Jt
Brighton and Sussex Medical School, Brighton UK and Royal Sussex County Hospital, Brighton, UK.
Brighton and Sussex Medical School, Brighton UK and consultant haematologist, Royal Sussex County Hospital, Brighton, UK
Clin Med (Lond). 2020 May 15;20(3):278-281. doi: 10.7861/clinmed.2020-0129.
The novel coronavirus SARS-CoV-2, causing the disease COVID-19, first emerged in Wuhan, China in December 2019 and has now spread to 203 countries or territories, infected over 2 million people and caused over 133,000 deaths. There is an urgent need for specific treatments. One potential treatment is chloroquine and its derivatives, including hydroxychloroquine, which have both antiviral and anti-inflammatory effects. These compounds are effective against SARS-CoV-2 , but data are lacking. Although some encouraging outcomes have been reported, and these results have been received enthusiastically, we recommend careful and critical evaluation of current evidence only when all methods and data are available for peer review. Chloroquine is safe and cheap. However, further evidence from coordinated multicentre trials is required before it can be confidently said whether it is effective against the current pandemic.
新型冠状病毒SARS-CoV-2引发了COVID-19疾病，于2019年12月首次在中国武汉出现，目前已传播至203个国家或地区，感染人数超过200万，导致超过13.3万人死亡。迫切需要特效治疗方法。一种潜在的治疗方法是氯喹及其衍生物，包括羟氯喹，它们具有抗病毒和抗炎作用。这些化合物对SARS-CoV-2有效，但缺乏相关数据。尽管已有一些令人鼓舞的结果报道，且这些结果受到了热烈欢迎，但我们建议仅在所有方法和数据可供同行评审时，才对现有证据进行谨慎和批判性评估。氯喹安全且便宜。然而，在能够确定其对当前疫情是否有效之前，还需要来自多中心协作试验的进一步证据。
