Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon.
Clinical Research Education, Networking & Consultancy (CRENC), Douala, Cameroon.
BMJ Open. 2020 Apr 16;10(4):e032042. doi: 10.1136/bmjopen-2019-032042.
Anaemia, especially in children aged <5 years, is a global health problem disproportionately affecting populations in low-income and middle-income countries. It is associated with high disability and death rates and has a negative effect on development. This study seeks to evaluate the prevalence and determinants of anaemia in children aged 6-59 months residing in Africa.
This protocol was prepared using the 2015 Preferred Reporting Items for Systematic Reviews and Meta-analyses for Protocols guidelines. Relevant citations will be identified by searching EMBASE, Web of Science, PubMed, Global Medicus Index and African Journals Online from inception to 30 September 2019 with no language restrictions. Two authors will independently screen and select eligible studies for the review. Random-effect meta-analytic methods will be used to pool study-specific estimates and heterogeneity will be assessed and quantified using the χ test on Cochrane's Q and I statistics, respectively. Publication bias will be evaluated using funnel plots and Egger's test. Subgroup analysis and multiple meta-regression using backward elimination will be performed to investigate sources of substantial heterogeneity.
No ethical approval is required for this study as it is based on already published data. The findings of the review will be published in a peer-reviewed journal and presented at conferences.
贫血，尤其是 5 岁以下儿童贫血，是一个全球性的健康问题，在中低收入国家的人群中尤为严重。它与高残疾和死亡率相关，并对发展产生负面影响。本研究旨在评估非洲 6-59 个月儿童贫血的患病率及其决定因素。
本方案按照 2015 年系统评价和荟萃分析优先报告条目（PRISMA）协议指南制定。将从建库至 2019 年 9 月 30 日，无语言限制，通过 EMBASE、Web of Science、PubMed、Global Medicus Index 和 African Journals Online 检索确定相关引文。两名作者将独立筛选和选择符合条件的研究进行综述。将使用随机效应荟萃分析方法汇总研究特定的估计值，并使用 Cochrane 的 Q 和 I 统计量上的 χ 检验评估和量化异质性，分别。将使用漏斗图和 Egger 检验评估发表偏倚。将进行亚组分析和多重逐步回归分析，以探讨存在大量异质性的原因。
本研究不需要伦理批准，因为它是基于已发表的数据。综述的结果将发表在同行评议的期刊上，并在会议上展示。
