Vocational High School of Health Services, Gazi University, 06830, Golbasi, Ankara, Turkey.
Environ Sci Pollut Res Int. 2020 Jul;27(19):23994-24003. doi: 10.1007/s11356-020-08716-1. Epub 2020 Apr 17.
Bisphenol A (BPA) received heightened attention in the recent years due to humans continuously being exposed to it. This study explores the effect of taurine or curcumin on subacute BPA treatment-induced nephrotoxicity in rats (Rattus norvegicus). Forty-two adult albino male rats were exposed to BPA (130 mg/kg daily) for 28 days by gastric gavage. BPA led to lipid peroxidation, inhibiting antioxidant enzyme activities like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST). BPA exposure also induced histopathological changes like tubular and glomerular degeneration, vascular congestion, and interstitial cell infiltration in kidney tissue. Cotreatment with taurine (100 mg/kg daily) or curcumin (100 mg/kg daily) alleviated the lipid peroxidation level and antioxidant enzyme activities and histological alterations brought about by BPA. In this study, curcumin and taurine application provided protection against renal toxicity caused by BPA but did not prevent toxic effect completely.
双酚 A（BPA）由于人类不断接触而在近年来受到高度关注。本研究探讨了牛磺酸或姜黄素对亚急性 BPA 处理诱导的大鼠（Rattus norvegicus）肾毒性的影响。42 只成年雄性白化大鼠通过胃灌胃每天暴露于 BPA（130mg/kg）28 天。BPA 导致脂质过氧化，抑制了抗氧化酶活性，如过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽 S-转移酶（GST）。BPA 暴露还导致组织学变化，如肾小管和肾小球退化、血管充血和间质细胞浸润。牛磺酸（100mg/kg 每日）或姜黄素（100mg/kg 每日）联合治疗减轻了 BPA 引起的脂质过氧化水平和抗氧化酶活性以及组织学改变。在这项研究中，姜黄素和牛磺酸的应用提供了对 BPA 引起的肾毒性的保护，但不能完全防止毒性作用。
