Aslanturk Ayse, Kalender Yusuf
Vocational High School of Health Se rvices, Gazi University, Ankara 06830, Turkey.
Faculty of Science, Department of Biology, Gazi University, Ankara 06560, Turkey.
Toxicol Res (Camb). 2021 Aug 26;10(5):1003-1012. doi: 10.1093/toxres/tfab080. eCollection 2021 Oct.
We investigated the ameliorative effect of the curcumin against methomyl-induced potential nephrotoxicity in Wistar albino male rats. In the present study, curcumin (100 mg kg bw), methomyl (0,8 mg kg bw) and methomyl plus curcumin were given to rats by oral for 28 days (for subacute examination). Concentrations of blood urea nitrogen, uric acid and creatinine in serum and malondialdehyde level and activities of antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase) and histopathological alterations in kidney tissues were studied. Methomyl caused an increment in the concentrations of blood urea nitrogen, creatinine, uric acid and MDA levels. In addition, methomyl caused a diminution in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase. Tubular and glomerular degenerations occurred in the kidney tissues of methomyl-received rats. However, coadministration of curcumin with methomyl significantly minimized the adverse effects of methomyl on kidney function parameters, lipid peroxidation and antioxidant enzyme activities and histological structure of kidney tissue. The results showed that curcumin significantly mitigated methomyl-induced nephrotoxicity in rats.
我们研究了姜黄素对灭多威诱导的Wistar白化雄性大鼠潜在肾毒性的改善作用。在本研究中，将姜黄素（100毫克/千克体重）、灭多威（0.8毫克/千克体重）以及灭多威加姜黄素经口给予大鼠28天（用于亚急性检查）。研究了血清中血尿素氮、尿酸和肌酐的浓度、丙二醛水平以及抗氧化酶（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽S转移酶）的活性，以及肾组织的组织病理学改变。灭多威导致血尿素氮、肌酐、尿酸浓度和丙二醛水平升高。此外，灭多威导致超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽S转移酶的活性降低。接受灭多威的大鼠肾组织出现肾小管和肾小球变性。然而，姜黄素与灭多威联合给药显著减轻了灭多威对肾功能参数、脂质过氧化、抗氧化酶活性以及肾组织组织结构的不良影响。结果表明，姜黄素能显著减轻灭多威诱导的大鼠肾毒性。
