Gazi University, Vocational High School of Health Services, Ankara, Turkey.
Environ Sci Pollut Res Int. 2019 Dec;26(36):37242-37253. doi: 10.1007/s11356-019-06615-8. Epub 2019 Nov 20.
Bisphenol A (BPA) is an estrogenic endocrine disrupting chemical to which humans are frequently exposed during routine daily life. Curcumin and taurine are natural products that have also been used as antioxidants against different environmental toxin-induced hepatotoxicity. Furthermore, they have protective and therapeutic effects against various diseases. The present investigation has been conducted to evaluate the therapeutic potential of curcumin (100 mg kg) and taurine (100 mg kg) for their hepatoprotective efficacy against BPA (130 mg kg)-induced liver injury in rat. BPA significantly elevated the levels of malondialdehyde (MDA), while it reduced the activities of catalase (CAT), total glutathione S-transferase (GST), total glutathione peroxidase (GPx), and total superoxide dismutase (SOD). Besides, these biochemical changes were accompanied by histopathological alterations marked by the destruction of normal liver structure. The histological examinations showed that exposure of BPA caused dilatation of sinusoids, inflammatory cell infiltration, congestion, and necrosis in liver parenchyma. The BPA-induced histopathological alterations in liver were minimized by curcumin and taurine treatment. Furthermore, no necrosis was observed in the liver tissues of curcumin plus BPA and taurine plus BPA-treated rats. Oral administration of curcumin and taurine to BPA-exposed rats significantly reversed the content of lipid peroxidation products, as well as enhanced the activities of GPx and GST, CAT, and SOD enzymes. These findings have indicated that curcumin and taurine might have a protective effect against BPA-induced hepatotoxicity in rats.
双酚 A (BPA) 是一种雌激素内分泌干扰化学物质，人类在日常生活中经常会接触到。姜黄素和牛磺酸是两种天然产物，也被用作抗氧化剂来对抗不同环境毒素引起的肝毒性。此外，它们对各种疾病具有保护和治疗作用。本研究旨在评估姜黄素（100mg/kg）和牛磺酸（100mg/kg）对 BPA（130mg/kg）诱导的大鼠肝损伤的治疗潜力。BPA 显著提高了丙二醛（MDA）的水平，同时降低了过氧化氢酶（CAT）、总谷胱甘肽 S-转移酶（GST）、总谷胱甘肽过氧化物酶（GPx）和总超氧化物歧化酶（SOD）的活性。此外，这些生化变化伴随着组织病理学改变，表现为正常肝结构的破坏。组织学检查显示，BPA 暴露导致窦扩张、炎症细胞浸润、充血和肝实质坏死。姜黄素和牛磺酸治疗可减轻 BPA 引起的肝组织病理学改变。此外，在姜黄素加 BPA 和牛磺酸加 BPA 处理的大鼠的肝组织中未观察到坏死。姜黄素和牛磺酸口服给予 BPA 暴露大鼠可显著逆转脂质过氧化产物的含量，并增强 GPx 和 GST、CAT 和 SOD 酶的活性。这些发现表明，姜黄素和牛磺酸可能对 BPA 诱导的大鼠肝毒性具有保护作用。
