Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.
Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12991-12997. doi: 10.1002/anie.202003823. Epub 2020 May 20.
DNA nanostructures with programmable nanoscale patterns has been achieved in the past decades, and molecular information coding (MIC) on those designed nanostructures has gained increasing attention for information security. However, achieving steganography and cryptography synchronously on DNA nanostructures remains a challenge. Herein, we demonstrated MIC in a reconfigurable DNA origami domino array (DODA), which can reconfigure intrinsic patterns but keep the DODA outline the same for steganography. When a set of keys (DNA strands) are added, the cryptographic data can be translated into visible patterns within DODA. More complex cryptography with the ASCII code within a programmable 6×6 lattice is demonstrated to demosntrate the versatility of MIC in the DODA. Furthermore, an anti-counterfeiting approach based on conformational transformation-mediated toehold strand displacement reaction is designed to protect MIC from decoding and falsification.
在过去的几十年中，已经实现了具有可编程纳米级图案的 DNA 纳米结构，并且那些设计的纳米结构上的分子信息编码 (MIC) 越来越受到信息安全的关注。然而，在 DNA 纳米结构上同时实现隐写术和密码术仍然是一个挑战。在这里，我们展示了在可重构 DNA 折纸多米诺骨牌阵列 (DODA) 中的 MIC，它可以重新配置内在的图案，但保持 DODA 轮廓相同用于隐写术。当添加一组密钥 (DNA 链) 时，加密数据可以转换为 DODA 内的可见图案。通过演示在可编程 6×6 格中的 ASCII 码的更复杂的密码术，展示了 MIC 在 DODA 中的多功能性。此外，还设计了一种基于构象转换介导的引发链置换反应的防伪方法，以保护 MIC 免受解码和伪造。
