Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Emergency and Critical Care Center, Mie University Hospital, Tsu, Mie, 514-8507, Japan.
Diagn Pathol. 2020 Apr 18;15(1):38. doi: 10.1186/s13000-020-00959-3.
Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches. The exosomes reaching the niches dynamically modify the gene expression and molecular architectures of the homing niche micro-environments. Cell adhesion molecule integrins regulate the tissue-specific homing patterns of not only cancer and immune cells, but also of the exosomes secreted from those cells. The exosome-mediated remodeling of the homing niches would affect immune lymphocyte migration and host defense, as well as cancer metastasis, thereby representing a potential therapeutic target.
外泌体是细胞外囊泡的一个重要亚群，参与了健康和疾病状态下的细胞间通讯。癌细胞和免疫细胞分泌的外泌体可转移至含有归巢龛的特定组织。到达归巢龛的外泌体可动态改变归巢龛微环境的基因表达和分子结构。细胞黏附分子整合素不仅调控着癌细胞和免疫细胞的组织特异性归巢模式，也调控着这些细胞分泌的外泌体的归巢模式。外泌体介导的归巢龛重塑会影响免疫淋巴细胞的迁移和宿主防御以及癌症转移，因此代表了一种潜在的治疗靶点。
